Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia
The study of language network plasticity following left hemisphere stroke is foundational to the understanding of aphasia recovery and neural plasticity in general. Damage in different language nodes may influence whether local plasticity is possible and whether right hemisphere recruitment is benef...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/8740353 |
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| author | Laura M. Skipper-Kallal Elizabeth H. Lacey Shihui Xing Peter E. Turkeltaub |
| author_facet | Laura M. Skipper-Kallal Elizabeth H. Lacey Shihui Xing Peter E. Turkeltaub |
| author_sort | Laura M. Skipper-Kallal |
| collection | DOAJ |
| description | The study of language network plasticity following left hemisphere stroke is foundational to the understanding of aphasia recovery and neural plasticity in general. Damage in different language nodes may influence whether local plasticity is possible and whether right hemisphere recruitment is beneficial. However, the relationships of both lesion size and location to patterns of remapping are poorly understood. In the context of a picture naming fMRI task, we tested whether lesion size and location relate to activity in surviving left hemisphere language nodes, as well as homotopic activity in the right hemisphere during covert name retrieval and overt name production. We found that lesion size was positively associated with greater right hemisphere activity during both phases of naming, a pattern that has frequently been suggested but has not previously been clearly demonstrated. During overt naming, lesions in the inferior frontal gyrus led to deactivation of contralateral frontal areas, while lesions in motor cortex led to increased right motor cortex activity. Furthermore, increased right motor activity related to better naming performance only when left motor cortex was lesioned, suggesting compensatory takeover of speech or language function by the homotopic node. These findings demonstrate that reorganization of language function, and the degree to which reorganization facilitates aphasia recovery, is dependent on the size and site of the lesion. |
| format | Article |
| id | doaj-art-3387b645142d4fbb8db0966be2a25e92 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3387b645142d4fbb8db0966be2a25e922025-08-20T03:55:12ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/87403538740353Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke AphasiaLaura M. Skipper-Kallal0Elizabeth H. Lacey1Shihui Xing2Peter E. Turkeltaub3Department of Neurology, Georgetown University Medical Center, Washington, DC, USADepartment of Neurology, Georgetown University Medical Center, Washington, DC, USADepartment of Neurology, Georgetown University Medical Center, Washington, DC, USADepartment of Neurology, Georgetown University Medical Center, Washington, DC, USAThe study of language network plasticity following left hemisphere stroke is foundational to the understanding of aphasia recovery and neural plasticity in general. Damage in different language nodes may influence whether local plasticity is possible and whether right hemisphere recruitment is beneficial. However, the relationships of both lesion size and location to patterns of remapping are poorly understood. In the context of a picture naming fMRI task, we tested whether lesion size and location relate to activity in surviving left hemisphere language nodes, as well as homotopic activity in the right hemisphere during covert name retrieval and overt name production. We found that lesion size was positively associated with greater right hemisphere activity during both phases of naming, a pattern that has frequently been suggested but has not previously been clearly demonstrated. During overt naming, lesions in the inferior frontal gyrus led to deactivation of contralateral frontal areas, while lesions in motor cortex led to increased right motor cortex activity. Furthermore, increased right motor activity related to better naming performance only when left motor cortex was lesioned, suggesting compensatory takeover of speech or language function by the homotopic node. These findings demonstrate that reorganization of language function, and the degree to which reorganization facilitates aphasia recovery, is dependent on the size and site of the lesion.http://dx.doi.org/10.1155/2017/8740353 |
| spellingShingle | Laura M. Skipper-Kallal Elizabeth H. Lacey Shihui Xing Peter E. Turkeltaub Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia Neural Plasticity |
| title | Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia |
| title_full | Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia |
| title_fullStr | Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia |
| title_full_unstemmed | Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia |
| title_short | Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia |
| title_sort | right hemisphere remapping of naming functions depends on lesion size and location in poststroke aphasia |
| url | http://dx.doi.org/10.1155/2017/8740353 |
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