Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression

Abstract Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency. The SERPINA1 mRNA has two distinct 3’ UTR isoforms, both of...

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Bibliographic Details
Main Authors: F. N. U. Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Polyadenylation
RNA processing
Interleukin 6 (IL-6)
Cirrhosis
SERPINA1
Alpha1 anti-trypsin (A1AT)
Online Access:https://doi.org/10.1038/s41598-025-07569-3
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