Evaluation of an engineered vascular graft exhibiting somatic growth in lambs to model repair of absent pulmonary artery branch

Evaluation of an engineered vascular graft exhibiting somatic growth in lambs to model repair of absent pulmonary artery branch

Abstract Background Growth is the holy grail of tissue implants in pediatrics. No vascular graft currently in use for surgical repairs of congenital heart defects has somatic growth capacity. Methods Biologically-engineered grafts (6 mm) grown from donor ovine fibroblasts in a sacrificial fibrin gel...

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Main Authors: Zeeshan H. Syedain, Matthew Lahti, Gurumurthy Hiremath, James Berry, John P. Carney, Jill Schappa Faustich, Tate Shannon, Andrea Rivera, Hadi Wiputra, Zhitian Shi, Richard Bianco, Robroy MacIver, John E. Mayer, Robert T. Tranquillo
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-024-00614-8
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