Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma
Hemodialysis (HD) is a critical treatment for patients with end-stage kidney disease (ESKD). The effectiveness of conventional dialyzers used there could be compromised during extended use due to limited blood compatibility of synthetic polymeric membranes and sub-optimal dialyzer design. In fact, b...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/15/1/16 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587983673360384 |
|---|---|
| author | David Ramada Bente Adema Mohamed Labib Odyl ter Beek Dimitrios Stamatialis |
| author_facet | David Ramada Bente Adema Mohamed Labib Odyl ter Beek Dimitrios Stamatialis |
| author_sort | David Ramada |
| collection | DOAJ |
| description | Hemodialysis (HD) is a critical treatment for patients with end-stage kidney disease (ESKD). The effectiveness of conventional dialyzers used there could be compromised during extended use due to limited blood compatibility of synthetic polymeric membranes and sub-optimal dialyzer design. In fact, blood flow in the hollow fiber (HF) membrane could trigger inflammatory responses and thrombus formation, leading to reduced filtration efficiency and limiting therapy duration, a consequence of flowing the patients’ blood through the lumen of each fiber while the dialysate passes along the inter-fiber space (IOF, inside-out filtration). This study investigates the development of HF membranes for “outside-in filtration” (OIF) in HD. In OIF, blood flows through the inter-fiber space while dialysate flows within the fiber lumens, reducing the risk of fiber clogging and potentially extending treatment duration. For the OIF mode, the membrane should have a blood-compatible outer selective layer in contact with the patient’s blood. We develop HFs for OIF via liquid-induced phase separation using PES/PVP (polyethersulphone/polyvinylpyrrolidone) blends. The fibers’ surface morphology (SEM, scanning electron microscopy), chemistry (ATR-FTIR—attenuated total reflection-Fourier transform infrared spectroscopy, XPS—X-ray photoelectron spectroscopy), transport properties, and uremic toxin removal from human plasma are evaluated and compared to commercial HFs. These membranes feature a smooth, hydrophilic outer layer, porous lumen, ultrafiltration coefficient of 13–34 mL m<sup>2</sup> h<sup>−1</sup> mmHg<sup>−1</sup>, adequate mechanical properties, low albumin leakage, and toxin removal performance on par with commercial membranes in IOF and OIF. They offer potential for more efficient long-term HD by reducing clogging and systemic anticoagulation needs and enhancing treatment time and toxin clearance. |
| format | Article |
| id | doaj-art-337e272c2593419788819f5440397e9d |
| institution | Kabale University |
| issn | 2077-0375 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj-art-337e272c2593419788819f5440397e9d2025-01-24T13:41:01ZengMDPI AGMembranes2077-03752025-01-011511610.3390/membranes15010016Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood PlasmaDavid Ramada0Bente Adema1Mohamed Labib2Odyl ter Beek3Dimitrios Stamatialis4Advanced Organ Bioengineering and Therapeutics, Faculty of Science and Technology, University of Twente, Zuidhorst 28, Drienerlolaan 5, 7522 NB Enschede, The NetherlandsAdvanced Organ Bioengineering and Therapeutics, Faculty of Science and Technology, University of Twente, Zuidhorst 28, Drienerlolaan 5, 7522 NB Enschede, The NetherlandsNovaFlux, 1 Wall Street, Princeton, NJ 08540, USAAdvanced Organ Bioengineering and Therapeutics, Faculty of Science and Technology, University of Twente, Zuidhorst 28, Drienerlolaan 5, 7522 NB Enschede, The NetherlandsAdvanced Organ Bioengineering and Therapeutics, Faculty of Science and Technology, University of Twente, Zuidhorst 28, Drienerlolaan 5, 7522 NB Enschede, The NetherlandsHemodialysis (HD) is a critical treatment for patients with end-stage kidney disease (ESKD). The effectiveness of conventional dialyzers used there could be compromised during extended use due to limited blood compatibility of synthetic polymeric membranes and sub-optimal dialyzer design. In fact, blood flow in the hollow fiber (HF) membrane could trigger inflammatory responses and thrombus formation, leading to reduced filtration efficiency and limiting therapy duration, a consequence of flowing the patients’ blood through the lumen of each fiber while the dialysate passes along the inter-fiber space (IOF, inside-out filtration). This study investigates the development of HF membranes for “outside-in filtration” (OIF) in HD. In OIF, blood flows through the inter-fiber space while dialysate flows within the fiber lumens, reducing the risk of fiber clogging and potentially extending treatment duration. For the OIF mode, the membrane should have a blood-compatible outer selective layer in contact with the patient’s blood. We develop HFs for OIF via liquid-induced phase separation using PES/PVP (polyethersulphone/polyvinylpyrrolidone) blends. The fibers’ surface morphology (SEM, scanning electron microscopy), chemistry (ATR-FTIR—attenuated total reflection-Fourier transform infrared spectroscopy, XPS—X-ray photoelectron spectroscopy), transport properties, and uremic toxin removal from human plasma are evaluated and compared to commercial HFs. These membranes feature a smooth, hydrophilic outer layer, porous lumen, ultrafiltration coefficient of 13–34 mL m<sup>2</sup> h<sup>−1</sup> mmHg<sup>−1</sup>, adequate mechanical properties, low albumin leakage, and toxin removal performance on par with commercial membranes in IOF and OIF. They offer potential for more efficient long-term HD by reducing clogging and systemic anticoagulation needs and enhancing treatment time and toxin clearance.https://www.mdpi.com/2077-0375/15/1/16end-stage kidney diseasehemodialysisdialyzersoutside-in filtration (OIF)blood compatibilitythrombus |
| spellingShingle | David Ramada Bente Adema Mohamed Labib Odyl ter Beek Dimitrios Stamatialis Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma Membranes end-stage kidney disease hemodialysis dialyzers outside-in filtration (OIF) blood compatibility thrombus |
| title | Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma |
| title_full | Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma |
| title_fullStr | Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma |
| title_full_unstemmed | Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma |
| title_short | Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma |
| title_sort | development of hollow fiber membranes suitable for outside in filtration of human blood plasma |
| topic | end-stage kidney disease hemodialysis dialyzers outside-in filtration (OIF) blood compatibility thrombus |
| url | https://www.mdpi.com/2077-0375/15/1/16 |
| work_keys_str_mv | AT davidramada developmentofhollowfibermembranessuitableforoutsideinfiltrationofhumanbloodplasma AT benteadema developmentofhollowfibermembranessuitableforoutsideinfiltrationofhumanbloodplasma AT mohamedlabib developmentofhollowfibermembranessuitableforoutsideinfiltrationofhumanbloodplasma AT odylterbeek developmentofhollowfibermembranessuitableforoutsideinfiltrationofhumanbloodplasma AT dimitriosstamatialis developmentofhollowfibermembranessuitableforoutsideinfiltrationofhumanbloodplasma |