Epigenetic Shifts in Preterm Neonatal Microbiome
Introduction and Study Aim: Preterm birth (<37 weeks) causes ~15 million births yearly and is a major contributor to neonatal morbidity and mortality [1]. These infants face developmental challenges, including disrupted microbial colonization and immature regulatory systems. Epigenetic modificat...
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Nicolaus Copernicus University in Toruń
2025-05-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/60029 |
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| author | Agnieszka Buliszak Piotr Marcjasz Anna Bioły Monika Babczyńska Agnieszka Borończyk Piotr Zając |
| author_facet | Agnieszka Buliszak Piotr Marcjasz Anna Bioły Monika Babczyńska Agnieszka Borończyk Piotr Zając |
| author_sort | Agnieszka Buliszak |
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Introduction and Study Aim: Preterm birth (<37 weeks) causes ~15 million births yearly and is a major contributor to neonatal morbidity and mortality [1]. These infants face developmental challenges, including disrupted microbial colonization and immature regulatory systems. Epigenetic modifications—heritable changes in gene expression without DNA sequence alteration—mediate environmental influences during this critical period [2]. This paper explores how the preterm microbiome and epigenetic mechanisms interact and influence health outcomes.
Brief Description of Current Knowledge: The preterm gut microbiome shows reduced diversity and more hospital-acquired bacteria [3]. Cesarean delivery, antibiotics, and lack of maternal microbes contribute to this dysbiosis. Beneficial colonizers (e.g., bifidobacteria) are reduced, while pathogens (e.g., Staphylococcus, Enterobacteriaceae) increase, linked to NEC and sepsis. Epigenetic shifts also occur rapidly in response to inflammation and stress [3]. Microbial metabolites (e.g., butyrate, folate) can alter epigenetic programming [5], and prenatal epigenetic states may shape microbial colonization [2].
Summary/Conclusions: Microbiome-epigenome interactions may shape immunity and development beyond infancy. Disruptions may imprint harmful epigenetic changes. More research is needed to clarify mechanisms and guide interventions like probiotics or epigenetic therapies.
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| format | Article |
| id | doaj-art-337d8c23c3dc4c27bfa33e6ddcf51ccd |
| institution | OA Journals |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
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| series | Quality in Sport |
| spelling | doaj-art-337d8c23c3dc4c27bfa33e6ddcf51ccd2025-08-20T01:47:40ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.60029Epigenetic Shifts in Preterm Neonatal MicrobiomeAgnieszka Buliszak0https://orcid.org/0009-0002-2434-4775Piotr Marcjasz1https://orcid.org/0009-0007-8247-5200Anna Bioły2https://orcid.org/0009-0005-2246-3537Monika Babczyńska3https://orcid.org/0009-0007-8430-5838Agnieszka Borończyk4https://orcid.org/0009-0001-3866-9370Piotr Zając5https://orcid.org/0009-0004-1516-8487Medical University of Silesia, Ul. Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, Ul. Poniatowskiego 15, 40-055 Katowice, Poland Medical University of Silesia, Ul. Poniatowskiego 15, 40-055 Katowice, Poland Medical University of Silesia, Ul. Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, Ul. Poniatowskiego 15, 40-055 Katowice, PolandUpper Silesian Medical Center of Prof. Leszek Giec of the Silesian Medical University, Ziołowa 45-47, 40-635 Katowice – Ochojec Introduction and Study Aim: Preterm birth (<37 weeks) causes ~15 million births yearly and is a major contributor to neonatal morbidity and mortality [1]. These infants face developmental challenges, including disrupted microbial colonization and immature regulatory systems. Epigenetic modifications—heritable changes in gene expression without DNA sequence alteration—mediate environmental influences during this critical period [2]. This paper explores how the preterm microbiome and epigenetic mechanisms interact and influence health outcomes. Brief Description of Current Knowledge: The preterm gut microbiome shows reduced diversity and more hospital-acquired bacteria [3]. Cesarean delivery, antibiotics, and lack of maternal microbes contribute to this dysbiosis. Beneficial colonizers (e.g., bifidobacteria) are reduced, while pathogens (e.g., Staphylococcus, Enterobacteriaceae) increase, linked to NEC and sepsis. Epigenetic shifts also occur rapidly in response to inflammation and stress [3]. Microbial metabolites (e.g., butyrate, folate) can alter epigenetic programming [5], and prenatal epigenetic states may shape microbial colonization [2]. Summary/Conclusions: Microbiome-epigenome interactions may shape immunity and development beyond infancy. Disruptions may imprint harmful epigenetic changes. More research is needed to clarify mechanisms and guide interventions like probiotics or epigenetic therapies. https://apcz.umk.pl/QS/article/view/60029Gut microbiomePreterm infantsNeonatal intensive careProbioticsMicrobial metabolitesIntrauterine inflammation |
| spellingShingle | Agnieszka Buliszak Piotr Marcjasz Anna Bioły Monika Babczyńska Agnieszka Borończyk Piotr Zając Epigenetic Shifts in Preterm Neonatal Microbiome Quality in Sport Gut microbiome Preterm infants Neonatal intensive care Probiotics Microbial metabolites Intrauterine inflammation |
| title | Epigenetic Shifts in Preterm Neonatal Microbiome |
| title_full | Epigenetic Shifts in Preterm Neonatal Microbiome |
| title_fullStr | Epigenetic Shifts in Preterm Neonatal Microbiome |
| title_full_unstemmed | Epigenetic Shifts in Preterm Neonatal Microbiome |
| title_short | Epigenetic Shifts in Preterm Neonatal Microbiome |
| title_sort | epigenetic shifts in preterm neonatal microbiome |
| topic | Gut microbiome Preterm infants Neonatal intensive care Probiotics Microbial metabolites Intrauterine inflammation |
| url | https://apcz.umk.pl/QS/article/view/60029 |
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