Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces
ABSTRACT Objective To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular. Methods A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non‐zwitt...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Laryngoscope Investigative Otolaryngology |
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| Online Access: | https://doi.org/10.1002/lio2.70118 |
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| author | Ryan Horne Caleb Escudero Morgan Ellerman C. Allan Guymon Marlan Hansen |
| author_facet | Ryan Horne Caleb Escudero Morgan Ellerman C. Allan Guymon Marlan Hansen |
| author_sort | Ryan Horne |
| collection | DOAJ |
| description | ABSTRACT Objective To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular. Methods A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non‐zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging. Results Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems. Preliminary experiments show that these films may also shorten the time required for a mucus‐plugged tube to unplug when exposed to saline. Conclusion Zwitterionic and conventional hydrogel films on typical medical surfaces reduce resistance to mucus flow, increase mucus discharge, and may facilitate faster unplugging of dried mucus. These effects are the most pronounced on tubes of larger inner diameter (greater than 2.6 mm) and tend to dissipate for tubes of smaller diameter. These results may help guide future improvements to medical tubes intended to discharge mucus and ventilate, resulting in fewer complications for patients. Level of Evidence Level 2, randomized individual trial. |
| format | Article |
| id | doaj-art-337c7f96c0cd4f8caa5e52cd3ddc3f8d |
| institution | Kabale University |
| issn | 2378-8038 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj-art-337c7f96c0cd4f8caa5e52cd3ddc3f8d2025-08-20T03:53:43ZengWileyLaryngoscope Investigative Otolaryngology2378-80382025-04-01102n/an/a10.1002/lio2.70118Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal SurfacesRyan Horne0Caleb Escudero1Morgan Ellerman2C. Allan Guymon3Marlan Hansen4University of Iowa Carver College of Medicine Iowa City lowa USAUniversity of Iowa Carver College of Medicine Iowa City lowa USADepartment of Chemical and Biochemical Engineering University of Iowa lowa City lowa USADepartment of Chemical and Biochemical Engineering University of Iowa lowa City lowa USADepartment of Otolaryngology University of Iowa Hospitals and Clinics lowa City lowa USAABSTRACT Objective To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular. Methods A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non‐zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging. Results Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems. Preliminary experiments show that these films may also shorten the time required for a mucus‐plugged tube to unplug when exposed to saline. Conclusion Zwitterionic and conventional hydrogel films on typical medical surfaces reduce resistance to mucus flow, increase mucus discharge, and may facilitate faster unplugging of dried mucus. These effects are the most pronounced on tubes of larger inner diameter (greater than 2.6 mm) and tend to dissipate for tubes of smaller diameter. These results may help guide future improvements to medical tubes intended to discharge mucus and ventilate, resulting in fewer complications for patients. Level of Evidence Level 2, randomized individual trial.https://doi.org/10.1002/lio2.70118hydrogelmucusmucus pluggingphotografttracheostomy tubetympanostomy tube |
| spellingShingle | Ryan Horne Caleb Escudero Morgan Ellerman C. Allan Guymon Marlan Hansen Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces Laryngoscope Investigative Otolaryngology hydrogel mucus mucus plugging photograft tracheostomy tube tympanostomy tube |
| title | Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces |
| title_full | Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces |
| title_fullStr | Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces |
| title_full_unstemmed | Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces |
| title_short | Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces |
| title_sort | enhancing mucus flow and clearance by grafting zwitterionic hydrogel films to luminal surfaces |
| topic | hydrogel mucus mucus plugging photograft tracheostomy tube tympanostomy tube |
| url | https://doi.org/10.1002/lio2.70118 |
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