Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platform

Recently, enthusiasm for catalysts-based nanozymes in various catalytic systems has been growing significantly. However, the low catalytic capacity of reported enzyme-mimic catalysts has not met the requirements for practical applications. In this work, Co-Fe Prussian blue analogs yolk-shelled nanoc...

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Main Authors: Weiyan Shi, Xinning Zhang, Xin Yang, Long Bai, Jinsong Yu, Fei Xu, Tai Ye
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625003182
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author Weiyan Shi
Xinning Zhang
Xin Yang
Long Bai
Jinsong Yu
Fei Xu
Tai Ye
author_facet Weiyan Shi
Xinning Zhang
Xin Yang
Long Bai
Jinsong Yu
Fei Xu
Tai Ye
author_sort Weiyan Shi
collection DOAJ
description Recently, enthusiasm for catalysts-based nanozymes in various catalytic systems has been growing significantly. However, the low catalytic capacity of reported enzyme-mimic catalysts has not met the requirements for practical applications. In this work, Co-Fe Prussian blue analogs yolk-shelled nanocubes (Co-Fe PBAs YSHCs) successfully prepared by a template-assisted ion exchange method are demonstrated for efficient AA sensing. The as-prepared Co-Fe PBAs YSHCs display superior and desirable peroxidase-like activity. The unique YSHCs structures can expose large active sites and enhance the stability during the colorimetric sensing process. As a result, the Co-Fe PBAs YSHCs sensing platform can sensitively and accurately determine AA in both colorimetric and smartphone sensing modes, the wide linear ranges for AA were 1–95 μM with a low limit of detection of 0.9 μM. In addition, the Co-Fe PBAs YSHCs sensing platform can be explored for AA detection in human serum samples, yielding satisfactory recoveries. This work provides an ideal method for preparing catalysts and pioneers the investigation of nanozymes with peroxidase-like activity in biosensing platform.
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series Results in Chemistry
spelling doaj-art-33787203f0a5421db42e3226c5ab01062025-08-20T03:43:54ZengElsevierResults in Chemistry2211-71562025-07-011610233510.1016/j.rechem.2025.102335Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platformWeiyan Shi0Xinning Zhang1Xin Yang2Long Bai3Jinsong Yu4Fei Xu5Tai Ye6Shanghai Engineering Research Center of Food Rapid Detection, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR ChinaKey Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, Hunan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material, College of Chemistry and Materials Engineering, Huaihua University, Huaihua 418000, PR ChinaKey Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, Hunan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material, College of Chemistry and Materials Engineering, Huaihua University, Huaihua 418000, PR China; Corresponding authors.Shanghai Engineering Research Center of Food Rapid Detection, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR ChinaShanghai Engineering Research Center of Food Rapid Detection, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR ChinaShanghai Engineering Research Center of Food Rapid Detection, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR ChinaShanghai Engineering Research Center of Food Rapid Detection, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR China; Corresponding authors.Recently, enthusiasm for catalysts-based nanozymes in various catalytic systems has been growing significantly. However, the low catalytic capacity of reported enzyme-mimic catalysts has not met the requirements for practical applications. In this work, Co-Fe Prussian blue analogs yolk-shelled nanocubes (Co-Fe PBAs YSHCs) successfully prepared by a template-assisted ion exchange method are demonstrated for efficient AA sensing. The as-prepared Co-Fe PBAs YSHCs display superior and desirable peroxidase-like activity. The unique YSHCs structures can expose large active sites and enhance the stability during the colorimetric sensing process. As a result, the Co-Fe PBAs YSHCs sensing platform can sensitively and accurately determine AA in both colorimetric and smartphone sensing modes, the wide linear ranges for AA were 1–95 μM with a low limit of detection of 0.9 μM. In addition, the Co-Fe PBAs YSHCs sensing platform can be explored for AA detection in human serum samples, yielding satisfactory recoveries. This work provides an ideal method for preparing catalysts and pioneers the investigation of nanozymes with peroxidase-like activity in biosensing platform.http://www.sciencedirect.com/science/article/pii/S2211715625003182Ascorbic acidCo-Fe Prussian blue analogsTemplate-assistant ion exchangeNanozymesDual-mode
spellingShingle Weiyan Shi
Xinning Zhang
Xin Yang
Long Bai
Jinsong Yu
Fei Xu
Tai Ye
Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platform
Results in Chemistry
Ascorbic acid
Co-Fe Prussian blue analogs
Template-assistant ion exchange
Nanozymes
Dual-mode
title Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platform
title_full Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platform
title_fullStr Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platform
title_full_unstemmed Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platform
title_short Colorimetry/smartphone dual-mode sensing of ascorbic acid by a Co-Fe Prussian blue analog-based peroxidase-like platform
title_sort colorimetry smartphone dual mode sensing of ascorbic acid by a co fe prussian blue analog based peroxidase like platform
topic Ascorbic acid
Co-Fe Prussian blue analogs
Template-assistant ion exchange
Nanozymes
Dual-mode
url http://www.sciencedirect.com/science/article/pii/S2211715625003182
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