Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging
Abstract Background Assessing liver health and its determinants in the elderly is crucial. Lifestyle factors, including nutrition and exercise, may influence liver function. This study aimed to investigate the association between macronutrients and energy intake with serum levels of aminotransferase...
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BMC
2024-11-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-024-05445-9 |
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| author | Hossein Taghizadeh Bilondi Seyyed Mostafa Arabi Fatemeh Mohammadzadeh Seyed Reza Mirhafez Alireza Ostadrahimi |
| author_facet | Hossein Taghizadeh Bilondi Seyyed Mostafa Arabi Fatemeh Mohammadzadeh Seyed Reza Mirhafez Alireza Ostadrahimi |
| author_sort | Hossein Taghizadeh Bilondi |
| collection | DOAJ |
| description | Abstract Background Assessing liver health and its determinants in the elderly is crucial. Lifestyle factors, including nutrition and exercise, may influence liver function. This study aimed to investigate the association between macronutrients and energy intake with serum levels of aminotransferases in elderly Iranian athletes and non-athletes. Methods A cross-sectional study involving 811 elderly participants (369 athletes, 442 non-athletes) from the Neyshabur Longitudinal Study on Aging (NeLSA) was conducted. Dietary intake was assessed using a food frequency questionnaire. Serum Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured. Regression analyses were employed to evaluate the associations between macronutrient intake and liver enzymes, adjusting for potential confounding variables. Results In elderly athletes, higher calorie, protein, and carbohydrate intake were significantly associated with elevated ALT levels (p < 0.01 for all). Additionally, higher carbohydrate and calorie intake were linked to increased AST levels in athletes (p < 0.05 for both). For elderly non-athletes, only higher protein intake was significantly associated with increased ALT levels (p < 0.05), while no nutritional factors were associated with changes in AST levels. Conclusions This study revealed that higher calorie, protein, and carbohydrate intake were associated with elevated ALT and AST levels in elderly individuals, particularly athletes. For athletes, all three nutrients were linked to elevated ALT, while only carbohydrates and calories impacted AST. For non-athletes, only protein affected ALT. These findings suggest that tailored nutritional strategies may be necessary to preserve liver health in active aging populations. |
| format | Article |
| id | doaj-art-336dab4c7290435a9528b85d9335f41f |
| institution | DOAJ |
| issn | 1471-2318 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj-art-336dab4c7290435a9528b85d9335f41f2025-08-20T02:51:18ZengBMCBMC Geriatrics1471-23182024-11-0124111310.1186/s12877-024-05445-9Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on agingHossein Taghizadeh Bilondi0Seyyed Mostafa Arabi1Fatemeh Mohammadzadeh2Seyed Reza Mirhafez3Alireza Ostadrahimi4Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical SciencesHealthy Ageing Research Centre, Neyshabur University of Medical Sciences Department of Epidemiology and Biostatistics, School of Health, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences Noncommunicable Diseases Research Center, Neyshabur University of Medical SciencesNutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical SciencesAbstract Background Assessing liver health and its determinants in the elderly is crucial. Lifestyle factors, including nutrition and exercise, may influence liver function. This study aimed to investigate the association between macronutrients and energy intake with serum levels of aminotransferases in elderly Iranian athletes and non-athletes. Methods A cross-sectional study involving 811 elderly participants (369 athletes, 442 non-athletes) from the Neyshabur Longitudinal Study on Aging (NeLSA) was conducted. Dietary intake was assessed using a food frequency questionnaire. Serum Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured. Regression analyses were employed to evaluate the associations between macronutrient intake and liver enzymes, adjusting for potential confounding variables. Results In elderly athletes, higher calorie, protein, and carbohydrate intake were significantly associated with elevated ALT levels (p < 0.01 for all). Additionally, higher carbohydrate and calorie intake were linked to increased AST levels in athletes (p < 0.05 for both). For elderly non-athletes, only higher protein intake was significantly associated with increased ALT levels (p < 0.05), while no nutritional factors were associated with changes in AST levels. Conclusions This study revealed that higher calorie, protein, and carbohydrate intake were associated with elevated ALT and AST levels in elderly individuals, particularly athletes. For athletes, all three nutrients were linked to elevated ALT, while only carbohydrates and calories impacted AST. For non-athletes, only protein affected ALT. These findings suggest that tailored nutritional strategies may be necessary to preserve liver health in active aging populations.https://doi.org/10.1186/s12877-024-05445-9ElderlyAlanine aminotransferaseAspartate aminotransferaseMacronutrientsAthletes |
| spellingShingle | Hossein Taghizadeh Bilondi Seyyed Mostafa Arabi Fatemeh Mohammadzadeh Seyed Reza Mirhafez Alireza Ostadrahimi Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging BMC Geriatrics Elderly Alanine aminotransferase Aspartate aminotransferase Macronutrients Athletes |
| title | Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging |
| title_full | Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging |
| title_fullStr | Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging |
| title_full_unstemmed | Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging |
| title_short | Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging |
| title_sort | relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non athletes findings from the neyshabur longitudinal study on aging |
| topic | Elderly Alanine aminotransferase Aspartate aminotransferase Macronutrients Athletes |
| url | https://doi.org/10.1186/s12877-024-05445-9 |
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