Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids
In this study, nucleation and growth of bone-like hydroxyapatite (HAp) mineral in modified simulated body fluids (m-SBF) were induced on chitosan (CS) substrates, which were prepared by spin coating of chitosan on Ti substrate. The m-SBF showed a two fold increase in the concentrations of calcium an...
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| Format: | Article |
| Language: | English |
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Budapest University of Technology and Economics
2017-01-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0007433&mi=cd |
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| author | K. H. Park S. J. Kim M. J. Hwang H. J. Song Y. J. Park |
| author_facet | K. H. Park S. J. Kim M. J. Hwang H. J. Song Y. J. Park |
| author_sort | K. H. Park |
| collection | DOAJ |
| description | In this study, nucleation and growth of bone-like hydroxyapatite (HAp) mineral in modified simulated body fluids (m-SBF) were induced on chitosan (CS) substrates, which were prepared by spin coating of chitosan on Ti substrate. The m-SBF showed a two fold increase in the concentrations of calcium and phosphate ions compared to SBF, and the post-NaOH treatment provided stabilization of the coatings. The calcium phosphate/chitosan composite prepared in m-SBF showed homogeneous distribution of approximately 350 nm-sized spherical clusters composed of octacalcium phosphate (OCP; Ca8H2(PO4)6·5H2O) crystalline structure. Chitosan provided a control over the size of calcium phosphate prepared by immersion in m-SBF, and post-NaOH treatment supported the binding of calcium phosphate compound on the Ti surface. Post-NaOH treatment increased hydrophilicity and crystallinity of carbonate apatite, which increased its potential for biomedical application. |
| format | Article |
| id | doaj-art-336b232d965942aa827be6a1949ac607 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-336b232d965942aa827be6a1949ac6072025-08-20T03:33:13ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2017-01-01111142010.3144/expresspolymlett.2017.3Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluidsK. H. ParkS. J. KimM. J. HwangH. J. SongY. J. ParkIn this study, nucleation and growth of bone-like hydroxyapatite (HAp) mineral in modified simulated body fluids (m-SBF) were induced on chitosan (CS) substrates, which were prepared by spin coating of chitosan on Ti substrate. The m-SBF showed a two fold increase in the concentrations of calcium and phosphate ions compared to SBF, and the post-NaOH treatment provided stabilization of the coatings. The calcium phosphate/chitosan composite prepared in m-SBF showed homogeneous distribution of approximately 350 nm-sized spherical clusters composed of octacalcium phosphate (OCP; Ca8H2(PO4)6·5H2O) crystalline structure. Chitosan provided a control over the size of calcium phosphate prepared by immersion in m-SBF, and post-NaOH treatment supported the binding of calcium phosphate compound on the Ti surface. Post-NaOH treatment increased hydrophilicity and crystallinity of carbonate apatite, which increased its potential for biomedical application.http://www.expresspolymlett.com/letolt.php?file=EPL-0007433&mi=cdNanocompositesMineralizationChitosanSimulated body fluidCalcium phosphate |
| spellingShingle | K. H. Park S. J. Kim M. J. Hwang H. J. Song Y. J. Park Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids eXPRESS Polymer Letters Nanocomposites Mineralization Chitosan Simulated body fluid Calcium phosphate |
| title | Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids |
| title_full | Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids |
| title_fullStr | Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids |
| title_full_unstemmed | Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids |
| title_short | Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids |
| title_sort | biomimetic fabrication of calcium phosphate chitosan nanohybrid composite in modified simulated body fluids |
| topic | Nanocomposites Mineralization Chitosan Simulated body fluid Calcium phosphate |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0007433&mi=cd |
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