Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis
<p><strong>Background:</strong> multiple sclerosis modifying drugs are intended to reduce the frequency of relapses, delay the progression of disability, as well as the appearance of new lesions in the Central Nervous System.<br /><strong>Objective:</strong> to de...
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2022-10-01
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/5396 |
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| author | Làzaro Aurelio Vàzquez Gòmez Carlos Hidalgo Mesa Yunier Broche Pèrez Yanet Valdés Morales |
| author_facet | Làzaro Aurelio Vàzquez Gòmez Carlos Hidalgo Mesa Yunier Broche Pèrez Yanet Valdés Morales |
| author_sort | Làzaro Aurelio Vàzquez Gòmez |
| collection | DOAJ |
| description | <p><strong>Background:</strong> multiple sclerosis modifying drugs are intended to reduce the frequency of relapses, delay the progression of disability, as well as the appearance of new lesions in the Central Nervous System.<br /><strong>Objective:</strong> to determine the early indicators of response to treatment with IFNb-1a.<br /><strong>Methods:</strong> Observational, analytical longitudinal prospective cohort study in patients diagnosed with multiple sclerosis. Two study cohorts were formed, each with 39 patients.<br /><strong>Results:</strong> the mean and standard deviation of the expanded disability status scale at 36 months was 2.37 ± 1.86 in the study group and 3.15 ± 2.1 in the control group. In the outbreaks of .13 ± .33 in the study group and in the control group of .41 ± .59. New lesions in T2 after the first 12 months of treatment was 0.90 ± 1.16 for the study group and 1 ± 1.10 for the control. Extended-scale progression of disability status, pretreatment annualized relapse rate, age of disease onset, time since disease progression, and gadolinium-enhancing lesions were significantly associated with the odds ratio of older Probability of non-progression for the study group with respect to the control group for the combined variable progression by extended disability status scale and relapses.<br /><strong>Conclusions:</strong> early indicators of response to treatment with interferon beta-1a were identified; that help assess the response to treatment early, which has a positive impact on the evolution of the disease.</p> |
| format | Article |
| id | doaj-art-3369943653fb4a6398fffeb30b914d1a |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2022-10-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-3369943653fb4a6398fffeb30b914d1a2025-01-30T21:28:59ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2022-10-012058258332181Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosisLàzaro Aurelio Vàzquez Gòmez0Carlos Hidalgo Mesa1Yunier Broche Pèrez2Yanet Valdés Morales3Hospital Provincial Universitario Clínico-Quirúrgico Arnaldo Milián Castro. Santa Clara, Villa Clara. Cuba.Hospital Universitario Militar Clínico-Quirúrgico Manuel Piti Fajardo. Villa Clara. Cuba.Universidad Central Martha Abreus de las Villas. Cuba.Hospital Provincial Universitario Clínico-Quirúrgico Arnaldo Milián Castro. Santa Clara, Villa Clara. Cuba.<p><strong>Background:</strong> multiple sclerosis modifying drugs are intended to reduce the frequency of relapses, delay the progression of disability, as well as the appearance of new lesions in the Central Nervous System.<br /><strong>Objective:</strong> to determine the early indicators of response to treatment with IFNb-1a.<br /><strong>Methods:</strong> Observational, analytical longitudinal prospective cohort study in patients diagnosed with multiple sclerosis. Two study cohorts were formed, each with 39 patients.<br /><strong>Results:</strong> the mean and standard deviation of the expanded disability status scale at 36 months was 2.37 ± 1.86 in the study group and 3.15 ± 2.1 in the control group. In the outbreaks of .13 ± .33 in the study group and in the control group of .41 ± .59. New lesions in T2 after the first 12 months of treatment was 0.90 ± 1.16 for the study group and 1 ± 1.10 for the control. Extended-scale progression of disability status, pretreatment annualized relapse rate, age of disease onset, time since disease progression, and gadolinium-enhancing lesions were significantly associated with the odds ratio of older Probability of non-progression for the study group with respect to the control group for the combined variable progression by extended disability status scale and relapses.<br /><strong>Conclusions:</strong> early indicators of response to treatment with interferon beta-1a were identified; that help assess the response to treatment early, which has a positive impact on the evolution of the disease.</p>http://medisur.sld.cu/index.php/medisur/article/view/5396esclerosis múltipleesclerosis múltiple remitente-recurrenteinterferón beta-1a |
| spellingShingle | Làzaro Aurelio Vàzquez Gòmez Carlos Hidalgo Mesa Yunier Broche Pèrez Yanet Valdés Morales Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis Medisur esclerosis múltiple esclerosis múltiple remitente-recurrente interferón beta-1a |
| title | Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis |
| title_full | Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis |
| title_fullStr | Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis |
| title_full_unstemmed | Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis |
| title_short | Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis |
| title_sort | response to treatment with interferon beta 1a in patients with relapsing remitting multiple sclerosis |
| topic | esclerosis múltiple esclerosis múltiple remitente-recurrente interferón beta-1a |
| url | http://medisur.sld.cu/index.php/medisur/article/view/5396 |
| work_keys_str_mv | AT lazaroaureliovazquezgomez responsetotreatmentwithinterferonbeta1ainpatientswithrelapsingremittingmultiplesclerosis AT carloshidalgomesa responsetotreatmentwithinterferonbeta1ainpatientswithrelapsingremittingmultiplesclerosis AT yunierbrocheperez responsetotreatmentwithinterferonbeta1ainpatientswithrelapsingremittingmultiplesclerosis AT yanetvaldesmorales responsetotreatmentwithinterferonbeta1ainpatientswithrelapsingremittingmultiplesclerosis |