FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT
A brief review of current data on the generality of the epidemiology and molecular pathogenesis of breast cancer and benign breast diseases is presented. Currently, a type of mastopathy, fibrosclerosis/sclerosing adenosis, accompanied by the formation of microcalcifications, is considered as a beni...
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QUASAR, LLC
2019-06-01
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| Series: | Исследования и практика в медицине |
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| Online Access: | https://www.rpmj.ru/rpmj/article/view/402 |
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| author | E. L. Muyzhnek V. I. Kiselev O. E. Jakobs N. I. Rozhkova A. D. Kaprin I. I. Burdina S. B. Zapirova M. L. Mazo S. P. Prokopenko P. G. Labazanova |
| author_facet | E. L. Muyzhnek V. I. Kiselev O. E. Jakobs N. I. Rozhkova A. D. Kaprin I. I. Burdina S. B. Zapirova M. L. Mazo S. P. Prokopenko P. G. Labazanova |
| author_sort | E. L. Muyzhnek |
| collection | DOAJ |
| description | A brief review of current data on the generality of the epidemiology and molecular pathogenesis of breast cancer and benign breast diseases is presented. Currently, a type of mastopathy, fibrosclerosis/sclerosing adenosis, accompanied by the formation of microcalcifications, is considered as a benign pathological condition with a high risk of malignancy, and also as a pre-start condition of a possible transition of mastopathy to cancer. In the review is discussed the fundamental biological process of the epithelial-mesenchymal transition (EMT) as a molecular pathogenetic basis of this phenomenon. Identification of the above mentioned pathological changes using mammography and refined diagnostics using a vacuum aspiration biopsy allow timely treatment of fibrosclerosis and sclerosing adenosis with Indinol® Forto, a drug of pathogenetic action based on indole-3-carbinol, due to its multiple anticancer and oncoprophylactic activity, including ability to reverse at the epigenetic level the EMT process abnormally proceeding in these benign breast diseases. |
| format | Article |
| id | doaj-art-3368d4258cea4ecc8aa88aa8482c29bf |
| institution | Kabale University |
| issn | 2410-1893 |
| language | Russian |
| publishDate | 2019-06-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj-art-3368d4258cea4ecc8aa88aa8482c29bf2025-08-20T04:00:14ZrusQUASAR, LLCИсследования и практика в медицине2410-18932019-06-0162758510.17709/2409-2231-2019-6-2-8264FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENTE. L. Muyzhnek0V. I. Kiselev1O. E. Jakobs2N. I. Rozhkova3A. D. Kaprin4I. I. Burdina5S. B. Zapirova6M. L. Mazo7S. P. Prokopenko8P. G. Labazanova9Russian Scientific Center of Roentgen Radiology of the Ministry of Health of the Russian FederationAcademician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology of the Ministry of Health of the Russian Federation,P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University); National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationA brief review of current data on the generality of the epidemiology and molecular pathogenesis of breast cancer and benign breast diseases is presented. Currently, a type of mastopathy, fibrosclerosis/sclerosing adenosis, accompanied by the formation of microcalcifications, is considered as a benign pathological condition with a high risk of malignancy, and also as a pre-start condition of a possible transition of mastopathy to cancer. In the review is discussed the fundamental biological process of the epithelial-mesenchymal transition (EMT) as a molecular pathogenetic basis of this phenomenon. Identification of the above mentioned pathological changes using mammography and refined diagnostics using a vacuum aspiration biopsy allow timely treatment of fibrosclerosis and sclerosing adenosis with Indinol® Forto, a drug of pathogenetic action based on indole-3-carbinol, due to its multiple anticancer and oncoprophylactic activity, including ability to reverse at the epigenetic level the EMT process abnormally proceeding in these benign breast diseases.https://www.rpmj.ru/rpmj/article/view/402breastepithelial-mesenchymal transitionmicrocalcinatesdiagnosticspathogenetic treatment |
| spellingShingle | E. L. Muyzhnek V. I. Kiselev O. E. Jakobs N. I. Rozhkova A. D. Kaprin I. I. Burdina S. B. Zapirova M. L. Mazo S. P. Prokopenko P. G. Labazanova FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT Исследования и практика в медицине breast epithelial-mesenchymal transition microcalcinates diagnostics pathogenetic treatment |
| title | FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT |
| title_full | FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT |
| title_fullStr | FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT |
| title_full_unstemmed | FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT |
| title_short | FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT |
| title_sort | fibrosclerosis and sclerosing adenosis with microcalcifications in the breast molecular pathogenesis timely diagnosis and treatment |
| topic | breast epithelial-mesenchymal transition microcalcinates diagnostics pathogenetic treatment |
| url | https://www.rpmj.ru/rpmj/article/view/402 |
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