Screening and identification of potential target of 1′-acetoxychavicol acetate (ACA) in acquired lapatinib-resistant breast cancer

Screening and identification of potential target of 1′-acetoxychavicol acetate (ACA) in acquired lapatinib-resistant breast cancer

1′-Acetoxychavicol acetate (ACA) eliminates breast cancer cells via the HER2/MAPK/ERK1/2 and PI3K/AKT pathways, and it also directly influences endocrine resistance by both enhancing pro-apoptotic signals and suppressing pro-survival molecules. This study utilized bioinformatics to assess ACA target...

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Bibliographic Details
Main Authors: Febri Wulandari, Ahmad Fauzi, Muhammad Da'i, Mahmoud Mirzaei, Maryati, Kun Harismah
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
1′-acetoxychavicol acetate
Lapatinib-resistant
Bioinformatics
Breast cancer
Targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024168004
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