Mediterranean fever gene variants may prevent the development of lupus nephritis in Japanese patients with systemic lupus erythematosus

Mediterranean fever gene variants may prevent the development of lupus nephritis in Japanese patients with systemic lupus erythematosus

BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of immune tolerance, leading to systemic inflammation and organ damage. The Mediterranean fever (MEFV) gene, primarily linked to familial Mediterranean fever (FMF), has been suggested to have a protective rol...

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Bibliographic Details
Main Authors: Yushiro Endo, Tomohiro Koga, Lamiaa Mohamed, Yoshika Tsuji, Masataka Umeda, Hiroko Hayashi, Tatsuya Kishino, Atsushi Kawakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
Mediterranean fever variant
lupus nephritis
adaptive immunity
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571208/full
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