Factors affecting fatigue progression in multiple sclerosis patients
Abstract Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic re...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-80992-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559534348271616 |
|---|---|
| author | Dima Machtoub Callie Fares Hassan Sinan Moustafa Al Hariri Rim Nehme Joelle Chami Ronny Joukhdar Raya Tcheroyan Salim Adib Samia J. Khoury |
| author_facet | Dima Machtoub Callie Fares Hassan Sinan Moustafa Al Hariri Rim Nehme Joelle Chami Ronny Joukhdar Raya Tcheroyan Salim Adib Samia J. Khoury |
| author_sort | Dima Machtoub |
| collection | DOAJ |
| description | Abstract Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients. The primary outcome was a change in the Modified Fatigue Impact Scale-5 (MFIS-5) score from first to last visit during the study interval, from November 2018 to November 2020. The study found that progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications were significantly associated with negative fatigue outcomes. Meanwhile age, sex, smoking frequency, use of pain medications, disease-modifying therapies, BMI, number of relapses, visits, steroid courses, and co-morbidities did not show an association. The clinical characteristics associated with worsening fatigue include progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications. Further studies are needed in order to elucidate a causal relationship and determine whether the management of fatigue in patients with MS should include interventions that address the aforementioned variables to optimize patient care and improve quality of life. |
| format | Article |
| id | doaj-art-335f5909233e4783a63560ef28b0d935 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-335f5909233e4783a63560ef28b0d9352025-01-05T12:23:56ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-80992-0Factors affecting fatigue progression in multiple sclerosis patientsDima Machtoub0Callie Fares1Hassan Sinan2Moustafa Al Hariri3Rim Nehme4Joelle Chami5Ronny Joukhdar6Raya Tcheroyan7Salim Adib8Samia J. Khoury9Faculty of Medicine, American University of Beirut Medical CenterDepartment of Dermatology, American University of Beirut Medical CenterJohn Hopkins School of MedicineCollege of Medicine, QU Health Sector, Qatar UniversityFaculty of Medicine, American University of Beirut Medical CenterFaculty of Medicine, American University of Beirut Medical CenterFaculty of Medicine, American University of Beirut Medical CenterDepartment of Internal Medicine, Cooper University HospitalDepartment of Public Health, American University of BeirutNehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical CenterAbstract Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients. The primary outcome was a change in the Modified Fatigue Impact Scale-5 (MFIS-5) score from first to last visit during the study interval, from November 2018 to November 2020. The study found that progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications were significantly associated with negative fatigue outcomes. Meanwhile age, sex, smoking frequency, use of pain medications, disease-modifying therapies, BMI, number of relapses, visits, steroid courses, and co-morbidities did not show an association. The clinical characteristics associated with worsening fatigue include progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications. Further studies are needed in order to elucidate a causal relationship and determine whether the management of fatigue in patients with MS should include interventions that address the aforementioned variables to optimize patient care and improve quality of life.https://doi.org/10.1038/s41598-024-80992-0FatigueDepressionPainProgressive MSRelapse-remitting MS |
| spellingShingle | Dima Machtoub Callie Fares Hassan Sinan Moustafa Al Hariri Rim Nehme Joelle Chami Ronny Joukhdar Raya Tcheroyan Salim Adib Samia J. Khoury Factors affecting fatigue progression in multiple sclerosis patients Scientific Reports Fatigue Depression Pain Progressive MS Relapse-remitting MS |
| title | Factors affecting fatigue progression in multiple sclerosis patients |
| title_full | Factors affecting fatigue progression in multiple sclerosis patients |
| title_fullStr | Factors affecting fatigue progression in multiple sclerosis patients |
| title_full_unstemmed | Factors affecting fatigue progression in multiple sclerosis patients |
| title_short | Factors affecting fatigue progression in multiple sclerosis patients |
| title_sort | factors affecting fatigue progression in multiple sclerosis patients |
| topic | Fatigue Depression Pain Progressive MS Relapse-remitting MS |
| url | https://doi.org/10.1038/s41598-024-80992-0 |
| work_keys_str_mv | AT dimamachtoub factorsaffectingfatigueprogressioninmultiplesclerosispatients AT calliefares factorsaffectingfatigueprogressioninmultiplesclerosispatients AT hassansinan factorsaffectingfatigueprogressioninmultiplesclerosispatients AT moustafaalhariri factorsaffectingfatigueprogressioninmultiplesclerosispatients AT rimnehme factorsaffectingfatigueprogressioninmultiplesclerosispatients AT joellechami factorsaffectingfatigueprogressioninmultiplesclerosispatients AT ronnyjoukhdar factorsaffectingfatigueprogressioninmultiplesclerosispatients AT rayatcheroyan factorsaffectingfatigueprogressioninmultiplesclerosispatients AT salimadib factorsaffectingfatigueprogressioninmultiplesclerosispatients AT samiajkhoury factorsaffectingfatigueprogressioninmultiplesclerosispatients |