RECENT TECHNOLOGIES IN CONTROLLED RELEASE DRUG DELIVERY
Conventional drug delivery systems can be inadequate in many areas today due to limiting factors such as the narrow therapeutic window, complex dosing interval in long-term treatments, and systemic toxicity. Accordingly, a search has been carried out for new controlled drug delivery systems, which a...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Istanbul University Press
2022-06-01
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| Series: | Sabiad |
| Subjects: | |
| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/D49E40C0EBF54160B9E7D3B962A44EBF |
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| Summary: | Conventional drug delivery systems can be inadequate in many areas today due to limiting factors such as the narrow therapeutic window, complex dosing interval in long-term treatments, and systemic toxicity. Accordingly, a search has been carried out for new controlled drug delivery systems, which aim to localize the pharmacological activity of the drug to the desired area at the desired rate, and exhibit increased activity with less complications for more drugs. Better patient compliance can be achieved with microfluidic-based drug delivery systems, which have been developed to meet these needs, and better release control can be achieved with advanced drug applications. These systems, created by the control and manipulation of nano/micro-sized liquids, have taken their place in the controlled release platform with a unique character on a single chip. This review provides general information about controlled drug release, then discusses biomedical devices, one of the new technologies developed through advancing research, and the microfluidic devices (micropumps and microneedles) that they utilize. Their types, structures, properties, preparation techniques, where they can be used and related applications, the advantages they can bring to controlled drug delivery, and progress made on this subject are examined, with examples. |
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| ISSN: | 2651-4060 |