Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia
Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women ex...
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2020-12-01
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| author | David Brown Annelies Wilder-Smith Marília Dalva Turchi Adriana Tami Antoni Soriano-Arandes Maria Elisabeth Moreira Demócrito de Barros Miranda-Filho Marion Koopmans Thomas Jaenisch Patrícia Brasil Ricardo Arraes de Alencar Ximenes Luana Damasceno Barry Rockx Wayner Vieira De souza Philippe Mayaud Elizabeth B Brickley Carlo Giaquinto Bruno Hoen Daniel Lang Neal Alexander A E Ades Xavier de Lamballerie Ulisses Ramos Montarroyos Celina Maria Turchi Martelli Thalia Velho Barreto de Araújo Claire Thorne Fabiana Gordon Ernesto T A Marques Adriana Gomez Vivian I Avelino-Silva Moritz Pohl Kerstin D Rosenberger Sarah Esperanza Bethencourt Castillo Victor Hugo Borja Aburto Celia D C Christie Jose Eduardo Gotuzzo H Mauro Martins Teixeira Maria Consuelo Miranda J Glenn Morris Paola Mariela Saba Villarroel Carmen Soria Segarra Joshua Anzinger Valery Beau De Rochars Maria de Fatima Albuquerque Rafael F O França Hugo Lopez-Gatell Ramirez Maria G Guzman Rigan Louis Anyela Lozano Eric Martinez Ricard Ortiz Serrano Silvia P Salgado Aluizio Augusto Segurado Zilton F M Vasconcelos Isabelle Freire Tabosa Luis Angel Villar |
| author_facet | David Brown Annelies Wilder-Smith Marília Dalva Turchi Adriana Tami Antoni Soriano-Arandes Maria Elisabeth Moreira Demócrito de Barros Miranda-Filho Marion Koopmans Thomas Jaenisch Patrícia Brasil Ricardo Arraes de Alencar Ximenes Luana Damasceno Barry Rockx Wayner Vieira De souza Philippe Mayaud Elizabeth B Brickley Carlo Giaquinto Bruno Hoen Daniel Lang Neal Alexander A E Ades Xavier de Lamballerie Ulisses Ramos Montarroyos Celina Maria Turchi Martelli Thalia Velho Barreto de Araújo Claire Thorne Fabiana Gordon Ernesto T A Marques Adriana Gomez Vivian I Avelino-Silva Moritz Pohl Kerstin D Rosenberger Sarah Esperanza Bethencourt Castillo Victor Hugo Borja Aburto Celia D C Christie Jose Eduardo Gotuzzo H Mauro Martins Teixeira Maria Consuelo Miranda J Glenn Morris Paola Mariela Saba Villarroel Carmen Soria Segarra Joshua Anzinger Valery Beau De Rochars Maria de Fatima Albuquerque Rafael F O França Hugo Lopez-Gatell Ramirez Maria G Guzman Rigan Louis Anyela Lozano Eric Martinez Ricard Ortiz Serrano Silvia P Salgado Aluizio Augusto Segurado Zilton F M Vasconcelos Isabelle Freire Tabosa Luis Angel Villar |
| author_sort | David Brown |
| collection | DOAJ |
| description | Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities. |
| format | Article |
| id | doaj-art-335b41a1b17c438cadb0fa7eeeac3c93 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-335b41a1b17c438cadb0fa7eeeac3c932025-08-20T02:32:41ZengBMJ Publishing GroupBMJ Open2044-60552020-12-01101210.1136/bmjopen-2019-035307Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortiaDavid Brown0Annelies Wilder-Smith1Marília Dalva Turchi2Adriana Tami3Antoni Soriano-Arandes4Maria Elisabeth Moreira5Demócrito de Barros Miranda-Filho6Marion Koopmans7Thomas Jaenisch8Patrícia Brasil9Ricardo Arraes de Alencar Ximenes10Luana DamascenoBarry Rockx11Wayner Vieira De souza12Philippe Mayaud13Elizabeth B Brickley14Carlo Giaquinto15Bruno Hoen16Daniel Lang17Neal Alexander18A E Ades19Xavier de Lamballerie20Ulisses Ramos Montarroyos21Celina Maria Turchi Martelli22Thalia Velho Barreto de Araújo23Claire Thorne24Fabiana Gordon25Ernesto T A Marques26Adriana Gomez27Vivian I Avelino-Silva28Moritz Pohl29Kerstin D Rosenberger30Sarah Esperanza Bethencourt Castillo31Victor Hugo Borja Aburto32Celia D C Christie33Jose Eduardo Gotuzzo H34Mauro Martins Teixeira35Maria Consuelo Miranda36J Glenn Morris37Paola Mariela Saba Villarroel38Carmen Soria Segarra39Joshua AnzingerValery Beau De RocharsMaria de Fatima AlbuquerqueRafael F O FrançaHugo Lopez-Gatell RamirezMaria G GuzmanRigan LouisAnyela LozanoEric MartinezRicard Ortiz SerranoSilvia P SalgadoAluizio Augusto SeguradoZilton F M VasconcelosIsabelle Freire TabosaLuis Angel Villar2Department of Immunology, Westmead Hospital, Sydney, NSW, AustraliaLondon School of Hygiene & Tropical Medicine, London, London, UKInstitute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia, BrazilDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The NetherlandsPaediatric Infectious Diseases and Immunodeficiencies Unit, Children’s Hospital, Hospital Vall d`Hebron, Barcelona, SpainDepartment of Neonatology, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, BrazilDepartamento de Medicina Interna, Universidade de Pernambuco, Recife, PE, BrasilDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Infectious Diseases, Section Clinical Tropical Medicine, UniversitatsKlinikum Heidelberg, Heidelberg, GermanyInstituto de pesquisa Clínica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, BrazilDepartamento de Medicina Interna, Universidade de Pernambuco, Recife, PE, BrasilDepartment of Viroscience, Erasmus Universiteit Rotterdam, Rotterdam, Zuid-Holland, The NetherlandsInstituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil2 Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UKDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK10 Department of Woman’s and Child’s Health, University of Padova, Padua, ItalyService de Maladies Infectieuses et Tropicales, CHRU de Nancy, Vandoeuvre-les-Nancy, FranceUniversity of Toronto Ontario Institute for Studies in Education, Toronto, Ontario, CanadaFaculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK1University of Bristol, Bristol, UKUnité des Virus Émergents, IRD 190-Inserm 1207, Aix-Marseille University, Marseille, FranceInstituto de Ciências Biológicas, Universidade de Pernambuco, Recife, PE, BrasilInstituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, BrasilPostgraduate Programme in Public Health, Federal University of Pernambuco, Recife, Brazil, Recife, BrazilIntegrated Screening Outcomes Surveillance Service, part of the NHS Infectious Diseases in Pregnancy Screening programme, based at UCL Great Ormond Street Institute of Child Health, London, UKPopulation Health Sciences, University of Bristol, Bristol, UKInstituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil6UMIT- Clínica Tolima- Universidad del Tolima, Ibagué, ColombiaAIDS Healthcare Foundation Global Program, Los Angeles, California, USAbiostatisticianDepartment of Infectious Diseases, Section Clinical Tropical Medicine, UniversitatsKlinikum Heidelberg, Heidelberg, GermanyFacultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, VenezuelaMexican Institute of Social Security, Mexico City, MexicoDepartment of Child and Adolescent Health, University of the West Indies at Mona, Kingston, JamaicaInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, PeruUniversidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilUniversidad Industrial de Santander, Bucaramanga, ColombiaEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USACentro Nacional de Enfermedades Tropicales, Santa Cruz de la Sierra, Santa Cruz de la Sierra, BoliviaUniversidad Católica de Santiago de Guayaquil, Guayaquil, Guayas, EcuadorIntroduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.https://bmjopen.bmj.com/content/10/12/e035307.full |
| spellingShingle | David Brown Annelies Wilder-Smith Marília Dalva Turchi Adriana Tami Antoni Soriano-Arandes Maria Elisabeth Moreira Demócrito de Barros Miranda-Filho Marion Koopmans Thomas Jaenisch Patrícia Brasil Ricardo Arraes de Alencar Ximenes Luana Damasceno Barry Rockx Wayner Vieira De souza Philippe Mayaud Elizabeth B Brickley Carlo Giaquinto Bruno Hoen Daniel Lang Neal Alexander A E Ades Xavier de Lamballerie Ulisses Ramos Montarroyos Celina Maria Turchi Martelli Thalia Velho Barreto de Araújo Claire Thorne Fabiana Gordon Ernesto T A Marques Adriana Gomez Vivian I Avelino-Silva Moritz Pohl Kerstin D Rosenberger Sarah Esperanza Bethencourt Castillo Victor Hugo Borja Aburto Celia D C Christie Jose Eduardo Gotuzzo H Mauro Martins Teixeira Maria Consuelo Miranda J Glenn Morris Paola Mariela Saba Villarroel Carmen Soria Segarra Joshua Anzinger Valery Beau De Rochars Maria de Fatima Albuquerque Rafael F O França Hugo Lopez-Gatell Ramirez Maria G Guzman Rigan Louis Anyela Lozano Eric Martinez Ricard Ortiz Serrano Silvia P Salgado Aluizio Augusto Segurado Zilton F M Vasconcelos Isabelle Freire Tabosa Luis Angel Villar Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia BMJ Open |
| title | Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia |
| title_full | Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia |
| title_fullStr | Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia |
| title_full_unstemmed | Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia |
| title_short | Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia |
| title_sort | zika virus infection in pregnancy a protocol for the joint analysis of the prospective cohort studies of the zikalliance zikaplan and zikaction consortia |
| url | https://bmjopen.bmj.com/content/10/12/e035307.full |
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