Development of a Mechanism of Action-Reflective Cell-Based Reporter Gene Assay for Measuring Bioactivities of Therapeutic Glucagon-like Peptide-2 Analogues

Development of a Mechanism of Action-Reflective Cell-Based Reporter Gene Assay for Measuring Bioactivities of Therapeutic Glucagon-like Peptide-2 Analogues

Glucagon-like peptide-2 (GLP-2) is a gut hormone that plays a pivotal role in regulating intestinal epithelial cell growth and function, making it a promising therapeutic agent for intestinal damage and bone-related diseases. Nonetheless, the therapeutic potential of GLP-2 is substantially diminishe...

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Bibliographic Details
Main Authors: Xiaoming Zhang, Chunyan Li, Zhe Deng, Chenggang Liang, Jing Li
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
glucagon-like peptide-2 (GLP-2)
teduglutide
reporter gene assay
bioactivity
method validation
RNA sequencing
Online Access:https://www.mdpi.com/1420-3049/30/9/1915
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