The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study
Abstract Background: The lack of improvement in some endometriotic people's pain after surgery even while using hormone treatment may suggest an inappropriate response to routine hormonal therapies. Objective: This study aimed to determine a cut-off point for selecting the most appropriate trea...
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| Format: | Article |
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Shahid Sadoughi University of Medical Sciences
2024-09-01
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| Series: | International Journal of Reproductive BioMedicine |
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| Online Access: | https://doi.org/10.18502/ijrm.v22i7.16970 |
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| author | Tahereh Poordast Saeed Alborzi Ziba Kiani Navid Omidifar Elham Askary Kefayat Chamanara Mansoureh Shokripour Alimohammad Keshtvarz Hesam Abadi |
| author_facet | Tahereh Poordast Saeed Alborzi Ziba Kiani Navid Omidifar Elham Askary Kefayat Chamanara Mansoureh Shokripour Alimohammad Keshtvarz Hesam Abadi |
| author_sort | Tahereh Poordast |
| collection | DOAJ |
| description | Abstract Background: The lack of improvement in some endometriotic people's pain after surgery even while using hormone treatment may suggest an inappropriate response to routine hormonal therapies. Objective: This study aimed to determine a cut-off point for selecting the most appropriate treatment based on the hormone receptors of endometriotic lesions. Materials and Methods: In this cross-sectional study, by reviewing the medical records of participants and testing their archive samples and phone interviews (if needed), 86 symptomatic women after endometriosis surgery who were operated into governmental hospitals, Shahid Faghihi and Hazrate Zeinab Shiraz Iran were enrolled between March 2017 and March 2019. Women were divided into 2 groups: responsiveness (n = 73 for dysmenorrhea, n = 60 for dyspareunia) to medical treatment and surgery, and unresponsiveness (n = 13, n = 7). We examined the pathological slides of 86 women to determine the amount of hormone receptors and the relationship between the type of medical treatment and the level of hormone receptors on pain relief within 1 yr after surgery. Results: Based on the receiver operating characteristic curve, dysmenorrhea in the presence of tissue estrogen receptors > 60% (p = 0.1065), and dyspareunia in the presence of tissue progesterone receptors > 80% (p = 0.0001) responded well to medical treatment after surgery. In the presence of endometrioma-dysmenorrhea showed the best response to oral contraceptive pills (69.4%), while in deep infiltrative endometriosis-dyspareunia showed the best response to progesterone treatment (75%). Conclusion: Prescribing an appropriate hormone therapy based on a specific immunohistochemistry staining pattern can improve the life quality of postoperative endometriosis individuals. |
| format | Article |
| id | doaj-art-334a991393bf4f55a2d4e47f0eeb2112 |
| institution | OA Journals |
| issn | 2476-4108 2476-3772 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj-art-334a991393bf4f55a2d4e47f0eeb21122025-08-20T01:54:26ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722024-09-0122756757810.18502/ijrm.v22i7.16970ijrm.v22i7.16970The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional studyTahereh Poordast0Saeed Alborzi1Ziba Kiani2Navid Omidifar3Elham Askary4Kefayat Chamanara5Mansoureh Shokripour6Alimohammad Keshtvarz Hesam Abadi7 Department of Obstetrics and Gynecology, School of Medicine, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Obstetrics and Gynecology, School of Medicine, Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Obstetrics and Gynecology, School of Medicine, Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Obstetrics and Gynecology, School of Medicine, Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Obstetrics and Gynecology, School of Medicine, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.Abstract Background: The lack of improvement in some endometriotic people's pain after surgery even while using hormone treatment may suggest an inappropriate response to routine hormonal therapies. Objective: This study aimed to determine a cut-off point for selecting the most appropriate treatment based on the hormone receptors of endometriotic lesions. Materials and Methods: In this cross-sectional study, by reviewing the medical records of participants and testing their archive samples and phone interviews (if needed), 86 symptomatic women after endometriosis surgery who were operated into governmental hospitals, Shahid Faghihi and Hazrate Zeinab Shiraz Iran were enrolled between March 2017 and March 2019. Women were divided into 2 groups: responsiveness (n = 73 for dysmenorrhea, n = 60 for dyspareunia) to medical treatment and surgery, and unresponsiveness (n = 13, n = 7). We examined the pathological slides of 86 women to determine the amount of hormone receptors and the relationship between the type of medical treatment and the level of hormone receptors on pain relief within 1 yr after surgery. Results: Based on the receiver operating characteristic curve, dysmenorrhea in the presence of tissue estrogen receptors > 60% (p = 0.1065), and dyspareunia in the presence of tissue progesterone receptors > 80% (p = 0.0001) responded well to medical treatment after surgery. In the presence of endometrioma-dysmenorrhea showed the best response to oral contraceptive pills (69.4%), while in deep infiltrative endometriosis-dyspareunia showed the best response to progesterone treatment (75%). Conclusion: Prescribing an appropriate hormone therapy based on a specific immunohistochemistry staining pattern can improve the life quality of postoperative endometriosis individuals.https://doi.org/10.18502/ijrm.v22i7.16970endometriosis, estrogen receptor, progesterone receptor, recurrence. |
| spellingShingle | Tahereh Poordast Saeed Alborzi Ziba Kiani Navid Omidifar Elham Askary Kefayat Chamanara Mansoureh Shokripour Alimohammad Keshtvarz Hesam Abadi The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study International Journal of Reproductive BioMedicine endometriosis, estrogen receptor, progesterone receptor, recurrence. |
| title | The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study |
| title_full | The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study |
| title_fullStr | The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study |
| title_full_unstemmed | The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study |
| title_short | The role of progesterone and estrogen receptors in treatment choice after endometriosis surgery: A cross-sectional study |
| title_sort | role of progesterone and estrogen receptors in treatment choice after endometriosis surgery a cross sectional study |
| topic | endometriosis, estrogen receptor, progesterone receptor, recurrence. |
| url | https://doi.org/10.18502/ijrm.v22i7.16970 |
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