Recent advances in vascular thiol isomerases: insights into structures, functions in thrombosis and antithrombotic inhibitor development

Abstract Vascular thiol isomerases (VTIs) encompass proteins such as protein disulfide isomerase (PDI), endoplasmic reticulum protein 5 (ERp5), ERp46, ERp57, ERp72, thioredoxin-related transmembrane protein 1 (TMX1), and TMX4, and play pivotal functions in platelet aggregation and formation of throm...

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Bibliographic Details
Main Authors: Longguang Jiang, Cai Yuan, Robert Flaumenhaft, Mingdong Huang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Thrombosis Journal
Subjects:
Online Access:https://doi.org/10.1186/s12959-025-00699-8
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