How macrophages use extracellular calreticulin to chase their prey
Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with di...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2533494 |
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| _version_ | 1849319601909792768 |
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| author | Liwei Zhao Peng Liu Oliver Kepp Guido Kroemer |
| author_facet | Liwei Zhao Peng Liu Oliver Kepp Guido Kroemer |
| author_sort | Liwei Zhao |
| collection | DOAJ |
| description | Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with distinct implications for cancer immunity. |
| format | Article |
| id | doaj-art-3339856703254f4aa3cf6ea70b5d2da9 |
| institution | Kabale University |
| issn | 2162-402X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-3339856703254f4aa3cf6ea70b5d2da92025-08-20T03:50:22ZengTaylor & Francis GroupOncoImmunology2162-402X2025-12-0114110.1080/2162402X.2025.2533494How macrophages use extracellular calreticulin to chase their preyLiwei Zhao0Peng Liu1Oliver Kepp2Guido Kroemer3Centre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Université, Inserm, Equipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, FranceCentre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Université, Inserm, Equipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, FranceCentre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Université, Inserm, Equipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, FranceCentre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Université, Inserm, Equipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, FranceRecent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with distinct implications for cancer immunity.https://www.tandfonline.com/doi/10.1080/2162402X.2025.2533494Asialoglycanscancercell stressimmunotherapy |
| spellingShingle | Liwei Zhao Peng Liu Oliver Kepp Guido Kroemer How macrophages use extracellular calreticulin to chase their prey OncoImmunology Asialoglycans cancer cell stress immunotherapy |
| title | How macrophages use extracellular calreticulin to chase their prey |
| title_full | How macrophages use extracellular calreticulin to chase their prey |
| title_fullStr | How macrophages use extracellular calreticulin to chase their prey |
| title_full_unstemmed | How macrophages use extracellular calreticulin to chase their prey |
| title_short | How macrophages use extracellular calreticulin to chase their prey |
| title_sort | how macrophages use extracellular calreticulin to chase their prey |
| topic | Asialoglycans cancer cell stress immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2533494 |
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