The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients
Aim: Hypothermia is a rare complication of antipsychotic drugs but serious outcomes including death may result. In this study, we aimed to investigate body temperature alterations in acute phase of chlorpromazine treatment, the relationship of inflammatory indicators and risk factors for hypothermic...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2022-12-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2428787 |
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| author | Ates Duman Mehmet Ali Baş Faruk Çiçekci Jale Bengi Çelik Bülent Devrim Akçay Muhammed Emin Zora Ömür İlban |
| author_facet | Ates Duman Mehmet Ali Baş Faruk Çiçekci Jale Bengi Çelik Bülent Devrim Akçay Muhammed Emin Zora Ömür İlban |
| author_sort | Ates Duman |
| collection | DOAJ |
| description | Aim: Hypothermia is a rare complication of antipsychotic drugs but serious outcomes including death may result. In this study, we aimed to investigate body temperature alterations in acute phase of chlorpromazine treatment, the relationship of inflammatory indicators and risk factors for hypothermic effect in intensive care unit (ICU) patients.
Materials and methods: 63 intensive care patients who needed sedative treatment due to agitation were divided into two groups as Group 1 (n = 30) with temperatures ≤ 38°C, and Group 2 (n = 33) with temperatures > 38°C according to baseline body temperatures. Also, recurrent measurements for 12 hours were made at specific intervals following 25 mg intravenous chlorpromazine.
Results: In Group 1, decrease in body temperatures was significant from 4th to 12th hours (p < 0.01), while in Group 2, significant decreases in body temperatures at all measurement hours were observed (p < 0.01). Temperature changes (delta temperature) observed at specific measurement intervals were significantly higher in Group 2 compared to Group 1. That difference was statistically significant at all intervals except for ΔTemperature B-6 (p < 0.05). The odds of hypothermic effects by chlorpromazine were 16%, 46%, 3%, and 18% for Acute Physiology and Chronic Health Evaluation II, procalcitonin, C-reactive protein, and white blood cells, respectively.
Conclusion: Chlorpromazine treatment applied for agitation in ICU patients was associated with acute hypothermic effect. Severity of disease and comorbidities might increase risk of hypothermia, and inflammatory biomarkers might be predictors of adverse drug reaction. |
| format | Article |
| id | doaj-art-33362149e2cf4eccadf890b028289a18 |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-33362149e2cf4eccadf890b028289a182025-01-02T23:43:04ZengSelcuk University PressGenel Tıp Dergisi2602-37412022-12-0132665866510.54005/geneltip.1116922154The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit PatientsAtes Duman0Mehmet Ali Baş1Faruk Çiçekci2Jale Bengi Çelik3Bülent Devrim Akçay4Muhammed Emin Zora5Ömür İlban6SELÇUK ÜNİVERSİTESİSELÇUK ÜNİVERSİTESİSELÇUK ÜNİVERSİTESİSELÇUK ÜNİVERSİTESİSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE TIP FAKÜLTESİSELÇUK ÜNİVERSİTESİSELÇUK ÜNİVERSİTESİAim: Hypothermia is a rare complication of antipsychotic drugs but serious outcomes including death may result. In this study, we aimed to investigate body temperature alterations in acute phase of chlorpromazine treatment, the relationship of inflammatory indicators and risk factors for hypothermic effect in intensive care unit (ICU) patients. Materials and methods: 63 intensive care patients who needed sedative treatment due to agitation were divided into two groups as Group 1 (n = 30) with temperatures ≤ 38°C, and Group 2 (n = 33) with temperatures > 38°C according to baseline body temperatures. Also, recurrent measurements for 12 hours were made at specific intervals following 25 mg intravenous chlorpromazine. Results: In Group 1, decrease in body temperatures was significant from 4th to 12th hours (p < 0.01), while in Group 2, significant decreases in body temperatures at all measurement hours were observed (p < 0.01). Temperature changes (delta temperature) observed at specific measurement intervals were significantly higher in Group 2 compared to Group 1. That difference was statistically significant at all intervals except for ΔTemperature B-6 (p < 0.05). The odds of hypothermic effects by chlorpromazine were 16%, 46%, 3%, and 18% for Acute Physiology and Chronic Health Evaluation II, procalcitonin, C-reactive protein, and white blood cells, respectively. Conclusion: Chlorpromazine treatment applied for agitation in ICU patients was associated with acute hypothermic effect. Severity of disease and comorbidities might increase risk of hypothermia, and inflammatory biomarkers might be predictors of adverse drug reaction.https://dergipark.org.tr/tr/download/article-file/2428787adverse drug reactionbody temperature changeschlorpromazineintensive care unitpsychomotor agitation |
| spellingShingle | Ates Duman Mehmet Ali Baş Faruk Çiçekci Jale Bengi Çelik Bülent Devrim Akçay Muhammed Emin Zora Ömür İlban The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients Genel Tıp Dergisi adverse drug reaction body temperature changes chlorpromazine intensive care unit psychomotor agitation |
| title | The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients |
| title_full | The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients |
| title_fullStr | The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients |
| title_full_unstemmed | The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients |
| title_short | The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients |
| title_sort | acute effect of chlorpromazine on body temperature in intensive care unit patients |
| topic | adverse drug reaction body temperature changes chlorpromazine intensive care unit psychomotor agitation |
| url | https://dergipark.org.tr/tr/download/article-file/2428787 |
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