The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications
Polysaccharides, as complex carbohydrates, play a pivotal role in immune modulation and interactions with the gut microbiota. The diverse array of dietary polysaccharides influences gut microbial ecology, impacting immune responses, metabolism, and overall well-being. Despite their recognized benefi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1555414/full |
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| author | Ting Zhao Congyue Wang Yuhan Liu Bo Li Mingjia Shao Wuyang Zhao Chuang Zhou |
| author_facet | Ting Zhao Congyue Wang Yuhan Liu Bo Li Mingjia Shao Wuyang Zhao Chuang Zhou |
| author_sort | Ting Zhao |
| collection | DOAJ |
| description | Polysaccharides, as complex carbohydrates, play a pivotal role in immune modulation and interactions with the gut microbiota. The diverse array of dietary polysaccharides influences gut microbial ecology, impacting immune responses, metabolism, and overall well-being. Despite their recognized benefits, there is limited understanding of the precise mechanisms by which polysaccharides modulate the immune system through the gut microbiota. A comprehensive search of Web of Science, PubMed, Google Scholar, and Embase up to May 2024 was conducted to identify relevant studies. This study employs a systematic approach to explore the interplay between polysaccharides and the gut microbiota, focusing on cytokine-mediated and short-chain fatty acid (SCFA)-mediated pathways. The findings underscore the significant role of polysaccharides in shaping the composition and function of the gut microbiota, thereby influencing immune regulation and metabolic processes. However, further research is necessary to elucidate the detailed molecular mechanisms and translate these findings into clinical applications. |
| format | Article |
| id | doaj-art-333403c23e3643bcae2d68c3b2e7ddc0 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-333403c23e3643bcae2d68c3b2e7ddc02025-08-20T02:10:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15554141555414The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implicationsTing Zhao0Congyue Wang1Yuhan Liu2Bo Li3Mingjia Shao4Wuyang Zhao5Chuang Zhou6Department of Oncology, Ansteel Group General Hospital, Anshan, ChinaDepartment of Oncology, Ansteel Group General Hospital, Anshan, ChinaDepartment of Medical Oncology, Anshan Cancer Hospital, Anshan, ChinaDepartment of Oncology, Ansteel Group General Hospital, Anshan, ChinaDepartment of Oncology, Ansteel Group General Hospital, Anshan, ChinaDepartment of Oncology, Ansteel Group General Hospital, Anshan, ChinaDepartment of Oncology, Ansteel Group General Hospital, Anshan, ChinaPolysaccharides, as complex carbohydrates, play a pivotal role in immune modulation and interactions with the gut microbiota. The diverse array of dietary polysaccharides influences gut microbial ecology, impacting immune responses, metabolism, and overall well-being. Despite their recognized benefits, there is limited understanding of the precise mechanisms by which polysaccharides modulate the immune system through the gut microbiota. A comprehensive search of Web of Science, PubMed, Google Scholar, and Embase up to May 2024 was conducted to identify relevant studies. This study employs a systematic approach to explore the interplay between polysaccharides and the gut microbiota, focusing on cytokine-mediated and short-chain fatty acid (SCFA)-mediated pathways. The findings underscore the significant role of polysaccharides in shaping the composition and function of the gut microbiota, thereby influencing immune regulation and metabolic processes. However, further research is necessary to elucidate the detailed molecular mechanisms and translate these findings into clinical applications.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1555414/fullpolysaccharidesimmune regulationgut microbiotaSCFAscytokines |
| spellingShingle | Ting Zhao Congyue Wang Yuhan Liu Bo Li Mingjia Shao Wuyang Zhao Chuang Zhou The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications Frontiers in Immunology polysaccharides immune regulation gut microbiota SCFAs cytokines |
| title | The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications |
| title_full | The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications |
| title_fullStr | The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications |
| title_full_unstemmed | The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications |
| title_short | The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications |
| title_sort | role of polysaccharides in immune regulation through gut microbiota mechanisms and implications |
| topic | polysaccharides immune regulation gut microbiota SCFAs cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1555414/full |
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