Retrospective analysis and IMRT replanning of a 3D-CRT murine dose painting study for preclinical oxygen-guided radiotherapy

Retrospective analysis and IMRT replanning of a 3D-CRT murine dose painting study for preclinical oxygen-guided radiotherapy

Abstract A recent parallel-opposed 3D-conformal radiotherapy (3D-CRT) study in mice compared dose escalation (boost) in hypoxic (pO2 ≤ 10 torr) and non-hypoxic tumor subvolumes. They found a hypoxic boost led to significantly greater (p < 1e-4) tumor control probability than an equivalent non-hyp...

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Main Authors: Rajit Tummala, Erik Pearson, Avery Antes, Jordan M. Slagowski, Gage Redler, Rasmus Nilsson, Howard J. Halpern, Neslihan Sarigul, Ibrahim Ahmed, Daniela Olivera Velarde, Boris Epel, Inna Gertsenshteyn, Bulent Aydogan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-01716-6
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