Modeling the endocrine control of vitellogenin production in female rainbow trout
The rainbow trout endocrine system is sensitive to changes in annual day length, which is likely the principal environmental cue controlling its reproductive cycle. This study focuses on the endocrine regulation of vitellogenin (Vg) protein synthesis, which is the major egg yolk precursor in this fi...
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| Format: | Article |
| Language: | English |
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AIMS Press
2013-12-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2014.11.621 |
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| author | Kaitlin Sundling Gheorghe Craciun Irvin Schultz Sharon Hook James Nagler Tim Cavileer Joseph Verducci Yushi Liu Jonghan Kim William Hayton |
| author_facet | Kaitlin Sundling Gheorghe Craciun Irvin Schultz Sharon Hook James Nagler Tim Cavileer Joseph Verducci Yushi Liu Jonghan Kim William Hayton |
| author_sort | Kaitlin Sundling |
| collection | DOAJ |
| description | The rainbow trout endocrine system is sensitive to changes in annual day length, which is likely the principal environmental cue controlling its reproductive cycle. This study focuses on the endocrine regulation of vitellogenin (Vg) protein synthesis, which is the major egg yolk precursor in this fish species.We present a model of Vg production in female rainbowtrout which incorporates a biological pathway beginningwith sex steroid estradiol-17β levels in the plasma andconcluding with Vg secretion by the liver and sequestration in theoocytes. Numerical simulation results based on this model are comparedwith experimental data for estrogen receptor mRNA, Vg mRNA, and Vgin the plasma from female rainbow trout over a normal annual reproductivecycle. We also analyze the response of the model to parameter changes.The model is subsequently tested against experimental data from femaletrout under a compressed photoperiod regime. Comparison of numericaland experimental results suggests the possibility of a time-dependentchange in oocyte Vg uptake rate.This model is part of a larger effort that is developing a mathematical description of the endocrine control of reproduction in female rainbow trout. We anticipate that these mathematical and computational models will play an important role in future regulatory toxicity assessments and in the prediction of ecological risk. |
| format | Article |
| id | doaj-art-331ec02ee164423cb310245d224efe92 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-331ec02ee164423cb310245d224efe922025-01-24T02:28:12ZengAIMS PressMathematical Biosciences and Engineering1551-00182013-12-0111362163910.3934/mbe.2014.11.621Modeling the endocrine control of vitellogenin production in female rainbow troutKaitlin Sundling0Gheorghe Craciun1Irvin Schultz2Sharon Hook3James Nagler4Tim Cavileer5Joseph Verducci6Yushi Liu7Jonghan Kim8William Hayton9Department of Pathology, University of Wisconsin Hospital and Clinics, Madison WI 53792Department of Mathematics and Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706Battelle Pacific Northwest National Laboratory, Marine Sciences Laboratory, Sequim, WA 98382Battelle Pacific Northwest National Laboratory, Marine Sciences Laboratory, Sequim, WA 98382Department of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, ID 83844Department of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, ID 83844Department of Statistics, Ohio State University, Columbus, OH 43210Department of Statistics, Ohio State University, Columbus, OH 43210Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115Division of Pharmaceutics, Ohio State University, Columbus, OH 43210The rainbow trout endocrine system is sensitive to changes in annual day length, which is likely the principal environmental cue controlling its reproductive cycle. This study focuses on the endocrine regulation of vitellogenin (Vg) protein synthesis, which is the major egg yolk precursor in this fish species.We present a model of Vg production in female rainbowtrout which incorporates a biological pathway beginningwith sex steroid estradiol-17β levels in the plasma andconcluding with Vg secretion by the liver and sequestration in theoocytes. Numerical simulation results based on this model are comparedwith experimental data for estrogen receptor mRNA, Vg mRNA, and Vgin the plasma from female rainbow trout over a normal annual reproductivecycle. We also analyze the response of the model to parameter changes.The model is subsequently tested against experimental data from femaletrout under a compressed photoperiod regime. Comparison of numericaland experimental results suggests the possibility of a time-dependentchange in oocyte Vg uptake rate.This model is part of a larger effort that is developing a mathematical description of the endocrine control of reproduction in female rainbow trout. We anticipate that these mathematical and computational models will play an important role in future regulatory toxicity assessments and in the prediction of ecological risk.https://www.aimspress.com/article/doi/10.3934/mbe.2014.11.621endocrine controlpharmacokinetic/pharmacodynamic model.vitellogenin |
| spellingShingle | Kaitlin Sundling Gheorghe Craciun Irvin Schultz Sharon Hook James Nagler Tim Cavileer Joseph Verducci Yushi Liu Jonghan Kim William Hayton Modeling the endocrine control of vitellogenin production in female rainbow trout Mathematical Biosciences and Engineering endocrine control pharmacokinetic/pharmacodynamic model. vitellogenin |
| title | Modeling the endocrine control of vitellogenin production in female rainbow trout |
| title_full | Modeling the endocrine control of vitellogenin production in female rainbow trout |
| title_fullStr | Modeling the endocrine control of vitellogenin production in female rainbow trout |
| title_full_unstemmed | Modeling the endocrine control of vitellogenin production in female rainbow trout |
| title_short | Modeling the endocrine control of vitellogenin production in female rainbow trout |
| title_sort | modeling the endocrine control of vitellogenin production in female rainbow trout |
| topic | endocrine control pharmacokinetic/pharmacodynamic model. vitellogenin |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2014.11.621 |
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