Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease
<b>Background</b>: Diabetes has become one of the most challenging public health problems due to the alarming increase in prevalence and the morbidity and mortality attributed to its acute and chronic complications. <b>Objective:</b> This study aimed to investigate the develo...
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MDPI AG
2024-12-01
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| author | Luminita-Georgeta Confederat Roxana Stefan Mihaela-Iustina Condurache Oana-Maria Dragostin |
| author_facet | Luminita-Georgeta Confederat Roxana Stefan Mihaela-Iustina Condurache Oana-Maria Dragostin |
| author_sort | Luminita-Georgeta Confederat |
| collection | DOAJ |
| description | <b>Background</b>: Diabetes has become one of the most challenging public health problems due to the alarming increase in prevalence and the morbidity and mortality attributed to its acute and chronic complications. <b>Objective:</b> This study aimed to investigate the development of chronic microvascular complications in sulfonylureas-treated diabetic patients and their correlations with glycemic control, risk factors and duration of the disease. <b>Methods</b>: This study included 200 patients that presented to “Providența” Medical Center, Iași. The information was obtained in a retrospective manner based on the observation sheets of the patients. A database was created, analyzed and statistically processed using the <i>Microsoft Excel software</i> (Version 15) and the <i>chi-square test of independence</i>. <b>Results</b>: The prevalence of diabetic polyneuropathy was 33.5%, while diabetic retinopathy was found in 27% of cases. For diabetic polyneuropathy, the results of the statistical analysis demonstrated a statistically significant dependence of the risk factors hyperlipidemia (significance level = 0.01) and overweight/obesity (significance level = 0.05). For diabetic retinopathy, the results demonstrated a statistically significant dependence of the risk factors hypertension (significance level = 0.05) and hyperlipidemia (significance level = 0.01). <b>Conclusions</b>: The present study reveals a strong correlation between the presence of risk factors and the development of microvascular complications of diabetes. |
| format | Article |
| id | doaj-art-331e4c7210e34d508be0c3aa12dfedca |
| institution | Kabale University |
| issn | 2039-7283 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Clinics and Practice |
| spelling | doaj-art-331e4c7210e34d508be0c3aa12dfedca2025-01-24T13:27:40ZengMDPI AGClinics and Practice2039-72832024-12-01151710.3390/clinpract15010007Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the DiseaseLuminita-Georgeta Confederat0Roxana Stefan1Mihaela-Iustina Condurache2Oana-Maria Dragostin3Department of Biomedical Sciences, “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, 700115 Iași, Romania“Providența” Medical Center, 10 Ștefan Cel Mare Avenue, 700259 Iași, RomaniaDepartment of Biomedical Sciences, “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, 700115 Iași, RomaniaResearch Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800008 Galati, Romania<b>Background</b>: Diabetes has become one of the most challenging public health problems due to the alarming increase in prevalence and the morbidity and mortality attributed to its acute and chronic complications. <b>Objective:</b> This study aimed to investigate the development of chronic microvascular complications in sulfonylureas-treated diabetic patients and their correlations with glycemic control, risk factors and duration of the disease. <b>Methods</b>: This study included 200 patients that presented to “Providența” Medical Center, Iași. The information was obtained in a retrospective manner based on the observation sheets of the patients. A database was created, analyzed and statistically processed using the <i>Microsoft Excel software</i> (Version 15) and the <i>chi-square test of independence</i>. <b>Results</b>: The prevalence of diabetic polyneuropathy was 33.5%, while diabetic retinopathy was found in 27% of cases. For diabetic polyneuropathy, the results of the statistical analysis demonstrated a statistically significant dependence of the risk factors hyperlipidemia (significance level = 0.01) and overweight/obesity (significance level = 0.05). For diabetic retinopathy, the results demonstrated a statistically significant dependence of the risk factors hypertension (significance level = 0.05) and hyperlipidemia (significance level = 0.01). <b>Conclusions</b>: The present study reveals a strong correlation between the presence of risk factors and the development of microvascular complications of diabetes.https://www.mdpi.com/2039-7283/15/1/7diabetic patientssulfonylureasretrospective studychronic complicationsrisk factors |
| spellingShingle | Luminita-Georgeta Confederat Roxana Stefan Mihaela-Iustina Condurache Oana-Maria Dragostin Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease Clinics and Practice diabetic patients sulfonylureas retrospective study chronic complications risk factors |
| title | Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease |
| title_full | Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease |
| title_fullStr | Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease |
| title_full_unstemmed | Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease |
| title_short | Chronic Microvascular Complications in Sulfonylureas-Treated Diabetic Patients: Correlations with Glycemic Control, Risk Factors and Duration of the Disease |
| title_sort | chronic microvascular complications in sulfonylureas treated diabetic patients correlations with glycemic control risk factors and duration of the disease |
| topic | diabetic patients sulfonylureas retrospective study chronic complications risk factors |
| url | https://www.mdpi.com/2039-7283/15/1/7 |
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