The non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort study
Abstract Background The metabolic score for insulin resistance (METS-IR) is considered a novel, non-invasive, and validated assessment of insulin resistance (IR), which may contribute to a poor neurological prognosis after stroke. However, evidence on the correlation between METS-IR and stroke progn...
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2025-07-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04299-x |
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| author | Yingkai Gao Wenping Sun |
| author_facet | Yingkai Gao Wenping Sun |
| author_sort | Yingkai Gao |
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| description | Abstract Background The metabolic score for insulin resistance (METS-IR) is considered a novel, non-invasive, and validated assessment of insulin resistance (IR), which may contribute to a poor neurological prognosis after stroke. However, evidence on the correlation between METS-IR and stroke prognosis in populations with acute ischemic stroke (AIS) remains limited. Therefore, this research aims to assess the effect of METS-IR levels on three-month unfavorable outcomes after AIS. Methods This prospective cohort study enrolled 1,722 AIS subjects who received treatment at a Korean hospital. The effect of METS-IR levels on three-month unfavorable outcomes was analyzed using a binary logistic regression model, while smoothed curve fitting and generalized additive modeling were applied to investigate non-linear associations. Results There was a non-linear correlation between METS-IR and three-month unfavorable outcomes after AIS was identified in this study. An inflection point in this relationship was observed at a METS-IR value of 35.16. For METS-IR values ≤ 35.16, a significant negative correlation was detected, with higher METS-IR levels being associated with a reduced risk of three-month unfavorable outcomes (OR: 0.93, 95% CI: 0.89–0.97, P = 0.0009). Conversely, for METS-IR values above this threshold, the association was no longer statistically significant (OR: 1.02, 95% CI: 0.99–1.05, P = 0.2486). Conclusion Our findings revealed a non-linear negative correlation between the effect of METS-IR levels on three-month unfavorable prognosis in AIS subjects. |
| format | Article |
| id | doaj-art-331cbd6820f14c1a945bffac6584f6cd |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Neurology |
| spelling | doaj-art-331cbd6820f14c1a945bffac6584f6cd2025-08-20T03:45:32ZengBMCBMC Neurology1471-23772025-07-012511910.1186/s12883-025-04299-xThe non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort studyYingkai Gao0Wenping Sun1The First Hospital of Jilin UniversityDepartment of General Practice, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract Background The metabolic score for insulin resistance (METS-IR) is considered a novel, non-invasive, and validated assessment of insulin resistance (IR), which may contribute to a poor neurological prognosis after stroke. However, evidence on the correlation between METS-IR and stroke prognosis in populations with acute ischemic stroke (AIS) remains limited. Therefore, this research aims to assess the effect of METS-IR levels on three-month unfavorable outcomes after AIS. Methods This prospective cohort study enrolled 1,722 AIS subjects who received treatment at a Korean hospital. The effect of METS-IR levels on three-month unfavorable outcomes was analyzed using a binary logistic regression model, while smoothed curve fitting and generalized additive modeling were applied to investigate non-linear associations. Results There was a non-linear correlation between METS-IR and three-month unfavorable outcomes after AIS was identified in this study. An inflection point in this relationship was observed at a METS-IR value of 35.16. For METS-IR values ≤ 35.16, a significant negative correlation was detected, with higher METS-IR levels being associated with a reduced risk of three-month unfavorable outcomes (OR: 0.93, 95% CI: 0.89–0.97, P = 0.0009). Conversely, for METS-IR values above this threshold, the association was no longer statistically significant (OR: 1.02, 95% CI: 0.99–1.05, P = 0.2486). Conclusion Our findings revealed a non-linear negative correlation between the effect of METS-IR levels on three-month unfavorable prognosis in AIS subjects.https://doi.org/10.1186/s12883-025-04299-xMetabolic score for insulin resistanceAcute ischemic strokeUnfavorable outcomesNon-linear relationship |
| spellingShingle | Yingkai Gao Wenping Sun The non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort study BMC Neurology Metabolic score for insulin resistance Acute ischemic stroke Unfavorable outcomes Non-linear relationship |
| title | The non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort study |
| title_full | The non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort study |
| title_fullStr | The non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort study |
| title_full_unstemmed | The non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort study |
| title_short | The non-linear relationship between the metabolic score for insulin resistance and three-month outcomes in the individuals with acute ischemic stroke: a prospective Korean cohort study |
| title_sort | non linear relationship between the metabolic score for insulin resistance and three month outcomes in the individuals with acute ischemic stroke a prospective korean cohort study |
| topic | Metabolic score for insulin resistance Acute ischemic stroke Unfavorable outcomes Non-linear relationship |
| url | https://doi.org/10.1186/s12883-025-04299-x |
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