Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE)
Introduction A recently recognised form of chronic kidney disease (CKD) of unknown origin (CKDu) is afflicting communities, mostly in rural areas in several regions of the world. Prevalence studies are being conducted in a number of countries, using a standardised protocol, to estimate the distribut...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2019-09-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/9/e031169.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846151097289277440 |
|---|---|
| author | Antonio Bernabe-Ortiz Neil Pearce Hans Kromhout Pablo Perel Liam Smeeth Cristina O’Callaghan-Gordo Jason Glaser Kristina Jakobsson Dorothea Nitsch Ben Caplin Nalika Gunawardena Adeera Levin Vidhya Venugopal Marvin Gonzalez-Quiroz Sophie Hamilton Cristina O'Callaghan Gordo Rajiv Saran Ricardo Correa-Rotter Ajay Singh Giuseppe Remuzzi Emmanuel Burdmann Rick Johnson Phabdheep Kaur Pronpimolk Kongtip Magdalena Madero Rovalo Moffat Nyirenda Dorairaj Prabhkaran Narayan Prasad Nalika Gunawardenan |
| author_facet | Antonio Bernabe-Ortiz Neil Pearce Hans Kromhout Pablo Perel Liam Smeeth Cristina O’Callaghan-Gordo Jason Glaser Kristina Jakobsson Dorothea Nitsch Ben Caplin Nalika Gunawardena Adeera Levin Vidhya Venugopal Marvin Gonzalez-Quiroz Sophie Hamilton Cristina O'Callaghan Gordo Rajiv Saran Ricardo Correa-Rotter Ajay Singh Giuseppe Remuzzi Emmanuel Burdmann Rick Johnson Phabdheep Kaur Pronpimolk Kongtip Magdalena Madero Rovalo Moffat Nyirenda Dorairaj Prabhkaran Narayan Prasad Nalika Gunawardenan |
| author_sort | Antonio Bernabe-Ortiz |
| collection | DOAJ |
| description | Introduction A recently recognised form of chronic kidney disease (CKD) of unknown origin (CKDu) is afflicting communities, mostly in rural areas in several regions of the world. Prevalence studies are being conducted in a number of countries, using a standardised protocol, to estimate the distribution of estimated glomerular filtration rate (eGFR), and thus identify communities with a high prevalence of reduced glomerular filtration rate (GFR). In this paper, we propose a standardised minimum protocol for cohort studies in high-risk communities aimed at investigating the incidence of, and risk factors for, early kidney dysfunction.Methods and analysis This generic cohort protocol provides the information to establish a prospective population-based cohort study in low-income settings with a high prevalence of CKDu. This involves a baseline survey that included key elements from the DEGREE survey (eg, using the previously published DEGREE methodology) of a population-representative sample, and subsequent follow-up visits in young adults (without a pre-existing diagnosis of CKD (eGFR<60 mL/min/1.73m2), proteinuria or risk factors for CKD at baseline) over several years. Each visit involves a core questionnaire, and collection and storage of biological samples. Local capacity to measure serum creatinine will be required so that immediate feedback on kidney function can be provided to participants. After completion of follow-up, repeat measures of creatinine should be conducted in a central laboratory, using reference standards traceable to isotope dilution mass spectrometry (IDMS) quality control material to quantify the main outcome of eGFR decline over time, alongside a description of the early evolution of disease and risk factors for eGFR decline.Ethics and dissemination Ethical approval will be obtained by local researchers, and participants will provide informed consent before the study commences. Participants will typically receive feedback and advice on their laboratory results, and referral to a local health system where appropriate. |
| format | Article |
| id | doaj-art-331c27b313c746f3a8aef605ad7e11f5 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-331c27b313c746f3a8aef605ad7e11f52024-11-28T01:00:10ZengBMJ Publishing GroupBMJ Open2044-60552019-09-019910.1136/bmjopen-2019-031169Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE)Antonio Bernabe-Ortiz0Neil Pearce1Hans Kromhout2Pablo Perel3Liam Smeeth4Cristina O’Callaghan-GordoJason Glaser5Kristina Jakobsson6Dorothea Nitsch7Ben Caplin8Nalika Gunawardena9Adeera Levin10Vidhya Venugopal11Marvin Gonzalez-Quiroz12Sophie Hamilton13Cristina O'Callaghan Gordo14Rajiv Saran15Ricardo Correa-Rotter16Ajay Singh17Giuseppe Remuzzi18Emmanuel BurdmannRick JohnsonPhabdheep KaurPronpimolk KongtipMagdalena Madero RovaloMoffat Nyirenda19Dorairaj PrabhkaranNarayan PrasadNalika GunawardenanCRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, PeruMedical Statistics, London School of Hygiene and Tropical Medicine, London, UK1 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlandsprofessor of non-communicable disease epidemiologyprofessorLa Isla Network, Washington, DC, USAOccupational and Environmental Medicine, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, SwedenLondon School of Hygiene & Tropical Medicine Faculty of Epidemiology and Public Health, London, UK2University College London (UCL), Department of Renal Medicine, Royal Free Hospital, London, UK15 World Health Organization Country Office, Colombo, Sri LankaprofessorDepartment of Environmental Health and Engineering, Sri Ramachandra Institute of Higher Education and Research, Chennai, India2University College London, UK4 School of Public Health, Faculty of Medicine, Imperial College London, London, UK5 Campus Mar, Instituto de Salud Global Barcelona, Barcelona, SpainDepartment of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA11 Department of Nephrology and Mineral Metabolism, National Medical Science and Nutrition Institute Salvador Zubirán, Mexico City, Mexico5 Brigham and Women`s Hospital, Harvard Medical School, Boston, Massachusetts, USAIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, ItalyMRC/UVRI/LSHTM Uganda Research Unit, Medical Research Council Uganda, Entebbe, UgandaIntroduction A recently recognised form of chronic kidney disease (CKD) of unknown origin (CKDu) is afflicting communities, mostly in rural areas in several regions of the world. Prevalence studies are being conducted in a number of countries, using a standardised protocol, to estimate the distribution of estimated glomerular filtration rate (eGFR), and thus identify communities with a high prevalence of reduced glomerular filtration rate (GFR). In this paper, we propose a standardised minimum protocol for cohort studies in high-risk communities aimed at investigating the incidence of, and risk factors for, early kidney dysfunction.Methods and analysis This generic cohort protocol provides the information to establish a prospective population-based cohort study in low-income settings with a high prevalence of CKDu. This involves a baseline survey that included key elements from the DEGREE survey (eg, using the previously published DEGREE methodology) of a population-representative sample, and subsequent follow-up visits in young adults (without a pre-existing diagnosis of CKD (eGFR<60 mL/min/1.73m2), proteinuria or risk factors for CKD at baseline) over several years. Each visit involves a core questionnaire, and collection and storage of biological samples. Local capacity to measure serum creatinine will be required so that immediate feedback on kidney function can be provided to participants. After completion of follow-up, repeat measures of creatinine should be conducted in a central laboratory, using reference standards traceable to isotope dilution mass spectrometry (IDMS) quality control material to quantify the main outcome of eGFR decline over time, alongside a description of the early evolution of disease and risk factors for eGFR decline.Ethics and dissemination Ethical approval will be obtained by local researchers, and participants will provide informed consent before the study commences. Participants will typically receive feedback and advice on their laboratory results, and referral to a local health system where appropriate.https://bmjopen.bmj.com/content/9/9/e031169.full |
| spellingShingle | Antonio Bernabe-Ortiz Neil Pearce Hans Kromhout Pablo Perel Liam Smeeth Cristina O’Callaghan-Gordo Jason Glaser Kristina Jakobsson Dorothea Nitsch Ben Caplin Nalika Gunawardena Adeera Levin Vidhya Venugopal Marvin Gonzalez-Quiroz Sophie Hamilton Cristina O'Callaghan Gordo Rajiv Saran Ricardo Correa-Rotter Ajay Singh Giuseppe Remuzzi Emmanuel Burdmann Rick Johnson Phabdheep Kaur Pronpimolk Kongtip Magdalena Madero Rovalo Moffat Nyirenda Dorairaj Prabhkaran Narayan Prasad Nalika Gunawardenan Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) BMJ Open |
| title | Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) |
| title_full | Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) |
| title_fullStr | Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) |
| title_full_unstemmed | Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) |
| title_short | Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE) |
| title_sort | rationale and population based prospective cohort protocol for the disadvantaged populations at risk of decline in egfr co degree |
| url | https://bmjopen.bmj.com/content/9/9/e031169.full |
| work_keys_str_mv | AT antoniobernabeortiz rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT neilpearce rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT hanskromhout rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT pabloperel rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT liamsmeeth rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT cristinaocallaghangordo rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT jasonglaser rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT kristinajakobsson rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT dorotheanitsch rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT bencaplin rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT nalikagunawardena rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT adeeralevin rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT vidhyavenugopal rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT marvingonzalezquiroz rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT sophiehamilton rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT cristinaocallaghangordo rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT rajivsaran rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT ricardocorrearotter rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT ajaysingh rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT giusepperemuzzi rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT emmanuelburdmann rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT rickjohnson rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT phabdheepkaur rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT pronpimolkkongtip rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT magdalenamaderorovalo rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT moffatnyirenda rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT dorairajprabhkaran rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT narayanprasad rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree AT nalikagunawardenan rationaleandpopulationbasedprospectivecohortprotocolforthedisadvantagedpopulationsatriskofdeclineinegfrcodegree |