HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors

HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors

Abstract Herpes virus1(HSV1) is a neurotropic virus that has been linked to Alzheimer’s disease. An In-silico structural homology search using α -Bgtx, identified structural homology between HSV1 gD and the nicotinic receptor neurotoxin α-Bgtx. SPR binding studies using acetylcholine binding protein...

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Main Authors: Sabina Yeasmin, Kavita Sharma, Christopher Nicolet, Laura DeCristofano, Yeganeh Ataian, Arina Ranjit, Ali Aghazadeh-Habashi, Dong Xu, Marvin Schulte
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00109-w
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