Impact of time-restricted feeding on renal function in advanced chronic kidney disease patients
Abstract Objective This study investigated the effects of time-restricted feeding (TRF) without calorie restriction on renal function in patients with stage 3–5 chronic kidney disease (CKD). Study design and setting An analytical study conducted at Balıkesir University Faculty of Medicine, Türkiye,...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-07-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43162-025-00496-9 |
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| Summary: | Abstract Objective This study investigated the effects of time-restricted feeding (TRF) without calorie restriction on renal function in patients with stage 3–5 chronic kidney disease (CKD). Study design and setting An analytical study conducted at Balıkesir University Faculty of Medicine, Türkiye, between December 2021 and December 2022. Methodology Eighty-four CKD patients (18–70 years) were divided into a TRF group (n = 42) and a control group (n = 42) with free feeding. Baseline and follow-up measurements at 3 and 6 months included height, weight, waist circumference, blood pressure, eGFR, and urine protein-creatinine ratio. Statistical significance was set at p < 0.05. Results Renal function remained stable in the TRF group (p = 0.07), while the control group showed a significant decline (p < 0.01). There was no significant difference between groups in eGFR, urea, and creatinine changes, except for the urine protein–creatinine ratio (p = 0.04). A significant reduction in waist circumference was observed in the TRF group (p < 0.01). Conclusion TRF may serve as a non-pharmacological strategy to preserve renal function and reduce central obesity in moderate to advanced CKD patients not receiving renal replacement therapy. Given the increasing prevalence of CKD, TRF could be a simple, cost-effective addition to current management strategies. Further research is needed to validate its long-term benefits. |
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| ISSN: | 2090-9098 |