The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis
Remdesivir is a nucleoside analog prodrug with broad-spectrum antiviral activity, including against coronaviruses. This has prioritized the inclusion of remdesivir in coronavirus disease 2019 (COVID-19) clinical trials. The United States Food and Drug Administration has granted emergency use authori...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2020/8811798 |
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| author | Vincent Peyko Helena Ladd Anthony Cutrona |
| author_facet | Vincent Peyko Helena Ladd Anthony Cutrona |
| author_sort | Vincent Peyko |
| collection | DOAJ |
| description | Remdesivir is a nucleoside analog prodrug with broad-spectrum antiviral activity, including against coronaviruses. This has prioritized the inclusion of remdesivir in coronavirus disease 2019 (COVID-19) clinical trials. The United States Food and Drug Administration has granted emergency use authorization for remdesivir. This emergency use authorization does not recommend the use of remdesivir in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min unless the benefits outweigh the risks. To date, there are no studies and scant information in the literature evaluating remdesivir utilization in patients with eGFR less than 30 mL/min or receiving hemodialysis. With little utilization data for patients with acute or chronic kidney injury, remdesivir may not be considered, leaving this patient population without the opportunity of a potentially beneficial treatment option. We present a case of one patient with eGFR less than 30 mL/min that required hemodialysis in which remdesivir was safely initiated, with therapy completed without any serious adverse events. |
| format | Article |
| id | doaj-art-330e54dd74de4aa583d04bad36cf87ec |
| institution | OA Journals |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-330e54dd74de4aa583d04bad36cf87ec2025-08-20T02:24:18ZengWileyCase Reports in Infectious Diseases2090-66252090-66332020-01-01202010.1155/2020/88117988811798The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring HemodialysisVincent Peyko0Helena Ladd1Anthony Cutrona2Mercy Health–St Elizabeth Boardman Hospital, Department of Pharmacy, 8401 Market St., Boardman, Youngstown, OH 44512, USAMercy Health–St Elizabeth Boardman Hospital, Department of Pharmacy, 8401 Market St., Boardman, Youngstown, OH 44512, USANEO Infectious Diseases Associates, 540 Parmalee Ave., Ste. 610, Youngstown, OH 44510, USARemdesivir is a nucleoside analog prodrug with broad-spectrum antiviral activity, including against coronaviruses. This has prioritized the inclusion of remdesivir in coronavirus disease 2019 (COVID-19) clinical trials. The United States Food and Drug Administration has granted emergency use authorization for remdesivir. This emergency use authorization does not recommend the use of remdesivir in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min unless the benefits outweigh the risks. To date, there are no studies and scant information in the literature evaluating remdesivir utilization in patients with eGFR less than 30 mL/min or receiving hemodialysis. With little utilization data for patients with acute or chronic kidney injury, remdesivir may not be considered, leaving this patient population without the opportunity of a potentially beneficial treatment option. We present a case of one patient with eGFR less than 30 mL/min that required hemodialysis in which remdesivir was safely initiated, with therapy completed without any serious adverse events.http://dx.doi.org/10.1155/2020/8811798 |
| spellingShingle | Vincent Peyko Helena Ladd Anthony Cutrona The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis Case Reports in Infectious Diseases |
| title | The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis |
| title_full | The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis |
| title_fullStr | The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis |
| title_full_unstemmed | The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis |
| title_short | The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis |
| title_sort | safe administration of remdesivir in a patient with acute kidney injury requiring hemodialysis |
| url | http://dx.doi.org/10.1155/2020/8811798 |
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