Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging
Purpose: Accurate internal target volume (ITV) estimation is essential for effective and safe radiation therapy in liver cancer. This study evaluates the clinical value of an ultraquality 4-dimensional magnetic resonance imaging (UQ 4D-MRI) technique for ITV estimation. Methods and Materials: The UQ...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Advances in Radiation Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452109425000624 |
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| author | Yen-Peng Liao, Ph.D. Haonan Xiao, Ph.D. Peilin Wang, M.Sc. Tian Li, Ph.D. Todd A. Aguilera, M.D., Ph.D. Justin D. Visak, Ph.D. Andrew R. Godley, Ph.D. You Zhang, Ph.D. Jing Cai, Ph.D. Jie Deng, Ph.D. |
| author_facet | Yen-Peng Liao, Ph.D. Haonan Xiao, Ph.D. Peilin Wang, M.Sc. Tian Li, Ph.D. Todd A. Aguilera, M.D., Ph.D. Justin D. Visak, Ph.D. Andrew R. Godley, Ph.D. You Zhang, Ph.D. Jing Cai, Ph.D. Jie Deng, Ph.D. |
| author_sort | Yen-Peng Liao, Ph.D. |
| collection | DOAJ |
| description | Purpose: Accurate internal target volume (ITV) estimation is essential for effective and safe radiation therapy in liver cancer. This study evaluates the clinical value of an ultraquality 4-dimensional magnetic resonance imaging (UQ 4D-MRI) technique for ITV estimation. Methods and Materials: The UQ 4D-MRI technique maps motion information from a low spatial resolution dynamic volumetric MRI onto a high-resolution 3-dimensional MRI used for radiation treatment planning. It was validated using a motion phantom and data from 13 patients with liver cancer. ITV generated from UQ 4D-MRI (ITV4D) was compared with those obtained through isotropic expansions (ITV2 mm and ITV5 mm) and those measured using conventional 4D-computed tomography (computed tomography-based ITV, ITVCT) for each patient. Results: Phantom studies showed a displacement measurement difference of <5% between UQ 4D-MRI and single-slice 2-dimensional cine MRI. In patient studies, the maximum superior-inferior displacements of the tumor on UQ 4D-MRI showed no significant difference compared with single-slice 2-dimensional cine imaging (P = .985). Computed tomography-based ITV showed no significant difference (P = .72) with ITV4D, whereas ITV2 mm and ITV5 mm significantly overestimated the volume by 29.0% (P = .002) and 120.7% (P < .001) compared with ITV4D, respectively. Conclusions: UQ 4D-MRI enables accurate motion assessment for liver tumors, facilitating precise ITV delineation for radiation treatment planning. Despite uncertainties from artificial intelligence-based delineation and variations in patients’ respiratory patterns, UQ 4D-MRI excels at capturing tumor motion trajectories, potentially improving treatment planning accuracy and reducing margins in liver cancer radiation therapy. |
| format | Article |
| id | doaj-art-330c9519e83e4c7ea07c01b0132176d4 |
| institution | DOAJ |
| issn | 2452-1094 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Radiation Oncology |
| spelling | doaj-art-330c9519e83e4c7ea07c01b0132176d42025-08-20T02:55:07ZengElsevierAdvances in Radiation Oncology2452-10942025-06-0110610177410.1016/j.adro.2025.101774Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance ImagingYen-Peng Liao, Ph.D.0Haonan Xiao, Ph.D.1Peilin Wang, M.Sc.2Tian Li, Ph.D.3Todd A. Aguilera, M.D., Ph.D.4Justin D. Visak, Ph.D.5Andrew R. Godley, Ph.D.6You Zhang, Ph.D.7Jing Cai, Ph.D.8Jie Deng, Ph.D.9Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TexasDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China; Department of Radiation Physics, Shandong Cancer Hospital, Shandong, ChinaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Radiation Oncology, UT Southwestern Medical Center, Dallas, TexasDepartment of Radiation Oncology, UT Southwestern Medical Center, Dallas, TexasDepartment of Radiation Oncology, UT Southwestern Medical Center, Dallas, TexasDepartment of Radiation Oncology, UT Southwestern Medical Center, Dallas, TexasDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas; Corresponding author: Jie Deng, PhD.Purpose: Accurate internal target volume (ITV) estimation is essential for effective and safe radiation therapy in liver cancer. This study evaluates the clinical value of an ultraquality 4-dimensional magnetic resonance imaging (UQ 4D-MRI) technique for ITV estimation. Methods and Materials: The UQ 4D-MRI technique maps motion information from a low spatial resolution dynamic volumetric MRI onto a high-resolution 3-dimensional MRI used for radiation treatment planning. It was validated using a motion phantom and data from 13 patients with liver cancer. ITV generated from UQ 4D-MRI (ITV4D) was compared with those obtained through isotropic expansions (ITV2 mm and ITV5 mm) and those measured using conventional 4D-computed tomography (computed tomography-based ITV, ITVCT) for each patient. Results: Phantom studies showed a displacement measurement difference of <5% between UQ 4D-MRI and single-slice 2-dimensional cine MRI. In patient studies, the maximum superior-inferior displacements of the tumor on UQ 4D-MRI showed no significant difference compared with single-slice 2-dimensional cine imaging (P = .985). Computed tomography-based ITV showed no significant difference (P = .72) with ITV4D, whereas ITV2 mm and ITV5 mm significantly overestimated the volume by 29.0% (P = .002) and 120.7% (P < .001) compared with ITV4D, respectively. Conclusions: UQ 4D-MRI enables accurate motion assessment for liver tumors, facilitating precise ITV delineation for radiation treatment planning. Despite uncertainties from artificial intelligence-based delineation and variations in patients’ respiratory patterns, UQ 4D-MRI excels at capturing tumor motion trajectories, potentially improving treatment planning accuracy and reducing margins in liver cancer radiation therapy.http://www.sciencedirect.com/science/article/pii/S2452109425000624 |
| spellingShingle | Yen-Peng Liao, Ph.D. Haonan Xiao, Ph.D. Peilin Wang, M.Sc. Tian Li, Ph.D. Todd A. Aguilera, M.D., Ph.D. Justin D. Visak, Ph.D. Andrew R. Godley, Ph.D. You Zhang, Ph.D. Jing Cai, Ph.D. Jie Deng, Ph.D. Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging Advances in Radiation Oncology |
| title | Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging |
| title_full | Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging |
| title_fullStr | Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging |
| title_full_unstemmed | Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging |
| title_short | Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging |
| title_sort | internal target volume estimation for liver cancer radiation therapy using an ultra quality 4 dimensional magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2452109425000624 |
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