Regional analysis of APOE polymorphism in Alzheimer’s disease in Spain

Regional analysis of APOE polymorphism in Alzheimer’s disease in Spain

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with significant cognitive and functional impacts. Genetic factors, particularly the APOE gene and its allelic variants (ε2, ε3, ε4), play a critical role in AD susceptibility. This study analyzed the allelic frequency and...

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Main Authors:	Ignacio Pardo-Pérez, Leticia Sánchez-Valdeón, Ana García-Gallego, Brisamar Estébanez, Inés Casado-Verdejo, Jesús Antonio Fernández-Fernández, Carlos Méndez-Martínez, Laura Bello-Corral
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Series:	Scientific Reports
Subjects:	Alzheimer’s Disease APOE polymorphism Genetic Geographical distribution Life quality
Online Access:	https://doi.org/10.1038/s41598-025-98323-2
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