Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital
Introduction: Nausea and vomiting (NV) remain as side effects of chemotherapy, which has a detrimental effect on patients’ quality of life (QOL) and treatment adherence. This study aimed to determine the effect of chemotherapy-induced NV (CINV) on the QOL of patients with ovarian cancer treated with...
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Universitas Indonesia
2024-08-01
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| Series: | Makara Journal of Health Research |
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| Online Access: | https://scholarhub.ui.ac.id/mjhr/vol28/iss2/4/ |
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| author | Veinardi Madjid David Calvin Gatot Purwoto Tofan Widya Utami Tricia Dewi Anggraeni Dhanasari Vidiawati Hariyono Winarto |
| author_facet | Veinardi Madjid David Calvin Gatot Purwoto Tofan Widya Utami Tricia Dewi Anggraeni Dhanasari Vidiawati Hariyono Winarto |
| author_sort | Veinardi Madjid |
| collection | DOAJ |
| description | Introduction: Nausea and vomiting (NV) remain as side effects of chemotherapy, which has a detrimental effect on patients’ quality of life (QOL) and treatment adherence. This study aimed to determine the effect of chemotherapy-induced NV (CINV) on the QOL of patients with ovarian cancer treated with chemotherapy at Dr. Cipto Mangunkusumo Hospital (CMH).
Methods: We conducted a cross-sectional study in patients with ovarian cancer receiving first-line chemotherapy regimens of carboplatin and paclitaxel. The European Organisation for Research and Treatment helped translate the Quality-of-Life Questionnaire-OV28 (QLQ-OV28) into Indonesian and tested it in a preliminary study. The approved Indonesian version of the QLQ-OV28, with the Quality-of-Life Questionnaire-C30 (QLQ-C30), was then used to evaluate QOL before and 1 week after chemotherapy.
Results: Several symptom scales increased, whereas function scales decreased. Moreover, 72.5% had an increase in the NV symptom scale, whereas 67.5% had a decrease in patients’ scale after chemotherapy. CINV had a significant partial effect on reducing QOL (p = 0.047 and y = 12.208–0.432).
Conclusions: CINV has a significant influence on lowering the QOL of patients with ovarian cancer undergoing first-line chemotherapy regimens with carboplatin and paclitaxel in CMH. |
| format | Article |
| id | doaj-art-3309e11be96741f6bb5fffa4f0300e52 |
| institution | OA Journals |
| issn | 2356-3664 2356-3656 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj-art-3309e11be96741f6bb5fffa4f0300e522025-08-20T02:13:27ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562024-08-012829710510.7454/msk.v28i2.1626Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo HospitalVeinardi Madjid0David Calvin1Gatot Purwoto2Tofan Widya Utami3Tricia Dewi Anggraeni4Dhanasari Vidiawati5Hariyono Winarto6Gynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaFaculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaDepartment of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta 10310, IndonesiaGynecologic Oncology Division, Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaIntroduction: Nausea and vomiting (NV) remain as side effects of chemotherapy, which has a detrimental effect on patients’ quality of life (QOL) and treatment adherence. This study aimed to determine the effect of chemotherapy-induced NV (CINV) on the QOL of patients with ovarian cancer treated with chemotherapy at Dr. Cipto Mangunkusumo Hospital (CMH). Methods: We conducted a cross-sectional study in patients with ovarian cancer receiving first-line chemotherapy regimens of carboplatin and paclitaxel. The European Organisation for Research and Treatment helped translate the Quality-of-Life Questionnaire-OV28 (QLQ-OV28) into Indonesian and tested it in a preliminary study. The approved Indonesian version of the QLQ-OV28, with the Quality-of-Life Questionnaire-C30 (QLQ-C30), was then used to evaluate QOL before and 1 week after chemotherapy. Results: Several symptom scales increased, whereas function scales decreased. Moreover, 72.5% had an increase in the NV symptom scale, whereas 67.5% had a decrease in patients’ scale after chemotherapy. CINV had a significant partial effect on reducing QOL (p = 0.047 and y = 12.208–0.432). Conclusions: CINV has a significant influence on lowering the QOL of patients with ovarian cancer undergoing first-line chemotherapy regimens with carboplatin and paclitaxel in CMH.https://scholarhub.ui.ac.id/mjhr/vol28/iss2/4/chemotherapyindonesiaovarian neoplasmsquality of life |
| spellingShingle | Veinardi Madjid David Calvin Gatot Purwoto Tofan Widya Utami Tricia Dewi Anggraeni Dhanasari Vidiawati Hariyono Winarto Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital Makara Journal of Health Research chemotherapy indonesia ovarian neoplasms quality of life |
| title | Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital |
| title_full | Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital |
| title_fullStr | Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital |
| title_full_unstemmed | Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital |
| title_short | Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital |
| title_sort | correlation between chemotherapy induced nausea and vomiting with quality of life in patients with ovarian cancer at dr cipto mangunkusumo hospital |
| topic | chemotherapy indonesia ovarian neoplasms quality of life |
| url | https://scholarhub.ui.ac.id/mjhr/vol28/iss2/4/ |
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