Crystal structure reveals the hydrophilic R1 group impairs NDM-1–ligand binding via water penetration at L3

Crystal structure reveals the hydrophilic R1 group impairs NDM-1–ligand binding via water penetration at L3

The global spread of New Delhi metallo-β-lactamases (NDMs) has exacerbated the antimicrobial resistance crisis. This study resolved the crystal structure of NDM-1 hydrolyzing amoxicillin for the first time, revealed that the hydroxyl group in the R1 moiety of amoxicillin anchors a key water molecule...

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Bibliographic Details
Main Authors: Xiangrui Shi, Huijuan Yang, Yujie Dai, Hui Zhao, Yuhang Li, Yanxi Li, Xin Zhou, Hailong Yan, Qinghua Zhang, Wei Liu
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Journal of Structural Biology: X
Subjects:
NDM-1
Amoxicillin
L3
R1 group
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152425000145
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