Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials
The unique properties of insect silk have attracted attention for years to develop scaffolds for tissue engineering. Combining natural silks with synthetic polymers may benefit biocompatibility, mechanical strength, and elasticity. Silk-modified biomaterials are a promising choice for tissue enginee...
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MDPI AG
2025-05-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/6/199 |
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| author | Mateusz M. Urbaniak Mariusz Tszydel Konrad Szustakiewicz Aleksandra Szwed-Georgiou Bartłomiej Kryszak Marcin Włodarczyk Sylwia Michlewska Piotr Jóźwiak Tomislav Ivankovic Mikołaj K. Cybulski Karolina Rudnicka |
| author_facet | Mateusz M. Urbaniak Mariusz Tszydel Konrad Szustakiewicz Aleksandra Szwed-Georgiou Bartłomiej Kryszak Marcin Włodarczyk Sylwia Michlewska Piotr Jóźwiak Tomislav Ivankovic Mikołaj K. Cybulski Karolina Rudnicka |
| author_sort | Mateusz M. Urbaniak |
| collection | DOAJ |
| description | The unique properties of insect silk have attracted attention for years to develop scaffolds for tissue engineering. Combining natural silks with synthetic polymers may benefit biocompatibility, mechanical strength, and elasticity. Silk-modified biomaterials are a promising choice for tissue engineering due to their versatility, biocompatibility, and many processing methods. This study investigated the physicochemical and biological properties of biocomposites formed by combining caddisfly silk (<i>Hydropsyche angustipennis</i>) and polycaprolactone (PCL). The PCL foams modified with caddisfly silk demonstrated full cytocompatibility and enhanced fibroblast adhesion and proliferation compared to unmodified PCL. These silk-modified PCL foams also induced NF-κB signaling, which is crucial for initiating tissue regeneration. Notably, the antimicrobial properties of the silk-modified PCL foams remained consistent with those of unmodified PCL, suggesting that the addition of silk did not alter this aspect of performance. The findings suggest that caddisfly silk-modified PCL foams present a promising solution for future medical and dental applications, emphasizing the potential of alternative silk sources in tissue engineering. |
| format | Article |
| id | doaj-art-33074e803e1a48a8b92bc3f97d1ca483 |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-33074e803e1a48a8b92bc3f97d1ca4832025-08-20T03:27:33ZengMDPI AGJournal of Functional Biomaterials2079-49832025-05-0116619910.3390/jfb16060199Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired BiomaterialsMateusz M. Urbaniak0Mariusz Tszydel1Konrad Szustakiewicz2Aleksandra Szwed-Georgiou3Bartłomiej Kryszak4Marcin Włodarczyk5Sylwia Michlewska6Piotr Jóźwiak7Tomislav Ivankovic8Mikołaj K. Cybulski9Karolina Rudnicka10Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha, 90-237 Lodz, PolandDepartment of Ecology and Vertebrate Zoology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha, 90-237 Lodz, PolandDepartment of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, 27 Wyb. Wyspianskiego, 50-370 Wroclaw, PolandDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha, 90-237 Lodz, PolandDepartment of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, 27 Wyb. Wyspianskiego, 50-370 Wroclaw, PolandDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha, 90-237 Lodz, PolandLaboratory of Microscopic Imaging and Specialized Biological Techniques, Faculty of Biology and Environmental Protection, 12/16 Banacha, 90-237 Lodz, PolandDepartment of Invertebrate Zoology and Hydrobiology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha, 90-232 Lodz, PolandDivision of Microbiology, Faculty of Science, Department of Biology, University of Zagreb, Ravnice 48, 10000 Zagreb, CroatiaInstitute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, 6 Uniwersytetu Poznanskiego, 61-614 Poznan, PolandDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha, 90-237 Lodz, PolandThe unique properties of insect silk have attracted attention for years to develop scaffolds for tissue engineering. Combining natural silks with synthetic polymers may benefit biocompatibility, mechanical strength, and elasticity. Silk-modified biomaterials are a promising choice for tissue engineering due to their versatility, biocompatibility, and many processing methods. This study investigated the physicochemical and biological properties of biocomposites formed by combining caddisfly silk (<i>Hydropsyche angustipennis</i>) and polycaprolactone (PCL). The PCL foams modified with caddisfly silk demonstrated full cytocompatibility and enhanced fibroblast adhesion and proliferation compared to unmodified PCL. These silk-modified PCL foams also induced NF-κB signaling, which is crucial for initiating tissue regeneration. Notably, the antimicrobial properties of the silk-modified PCL foams remained consistent with those of unmodified PCL, suggesting that the addition of silk did not alter this aspect of performance. The findings suggest that caddisfly silk-modified PCL foams present a promising solution for future medical and dental applications, emphasizing the potential of alternative silk sources in tissue engineering.https://www.mdpi.com/2079-4983/16/6/199polycaprolactonecaddisflysilktissue regenerationnature-inspired biomaterials |
| spellingShingle | Mateusz M. Urbaniak Mariusz Tszydel Konrad Szustakiewicz Aleksandra Szwed-Georgiou Bartłomiej Kryszak Marcin Włodarczyk Sylwia Michlewska Piotr Jóźwiak Tomislav Ivankovic Mikołaj K. Cybulski Karolina Rudnicka Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials Journal of Functional Biomaterials polycaprolactone caddisfly silk tissue regeneration nature-inspired biomaterials |
| title | Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials |
| title_full | Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials |
| title_fullStr | Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials |
| title_full_unstemmed | Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials |
| title_short | Caddisfly Silk-Polycaprolactone Foams: Physicochemical and Biological Properties of Nature-Inspired Biomaterials |
| title_sort | caddisfly silk polycaprolactone foams physicochemical and biological properties of nature inspired biomaterials |
| topic | polycaprolactone caddisfly silk tissue regeneration nature-inspired biomaterials |
| url | https://www.mdpi.com/2079-4983/16/6/199 |
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