In vitro antiproliferative activity, docking study, and plausible mode of action of (+)-2,2′-epicytoskyrin A against breast cancer MCF-7 and T47D cell lines

In vitro antiproliferative activity, docking study, and plausible mode of action of (+)-2,2′-epicytoskyrin A against breast cancer MCF-7 and T47D cell lines

Abstract Background The endophytic fungus Diaporthe sp. GNBP-10 has been reported to produce metabolite bis-anthraquinone (+)-2,2′-epicytoskyrin A in high titers. In this study, we evaluated the potential of this metabolite as an anti-breast cancer agent by conducting antiproliferative activity stud...

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Main Authors: Agus Budiawan Naro Putra, Kartika Dyah Palupi, Ahmad Fathoni, Listiana Oktavia, Endah Puji Septisetyani, Arif Nurkanto, Praptiwi Praptiwi, Dewi Wulansari, Adi Santoso, Dwinna Rahmi, Andria Agusta
Format: Article
Language:English
Published: SpringerOpen 2025-05-01
Series:Beni-Suef University Journal of Basic and Applied Sciences
Subjects:
(+)-2,2′-Epicytoskyrin A
Antiproliferative
Diaporthe sp. GNBP-10
Uncaria gambier
Online Access:https://doi.org/10.1186/s43088-025-00632-y
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