iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis

iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis

BackgroundCryptococcal meningitis (CM) is a significant global health issue, particularly affecting individuals with HIV. Amphotericin B (AmB) serves as the cornerstone treatment for CM; however, its clinical application is restricted due to limited penetration of the blood–brain barrier and associa...

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Bibliographic Details
Main Authors: Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Microbiology
Subjects:
Cryptococcus neoformans
cryptococcal meningitis
amphotericin B
induced pluripotent stem cells
drug delivery systems
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1531425/full
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