High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays
Electrochemical impedance spectroscopy is mostly sensitive to the state of the electrode surface at low frequencies, where the electrical properties of the surrounding electrolyte do not yet dominate the response. The available frequency range increases linearly with the inverse electrode size, such...
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| Format: | Article |
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Elsevier
2025-06-01
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| Series: | Sensors and Actuators Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266605392500013X |
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| author | Selvaraj Chinnathambi Mohammad Saghafi Suryasnata Tripathy Frans P. Widdershoven Serge G. Lemay |
| author_facet | Selvaraj Chinnathambi Mohammad Saghafi Suryasnata Tripathy Frans P. Widdershoven Serge G. Lemay |
| author_sort | Selvaraj Chinnathambi |
| collection | DOAJ |
| description | Electrochemical impedance spectroscopy is mostly sensitive to the state of the electrode surface at low frequencies, where the electrical properties of the surrounding electrolyte do not yet dominate the response. The available frequency range increases linearly with the inverse electrode size, such that miniaturized electrodes offer the ability to probe the surface at higher frequencies. Measuring the AC response of miniaturized electrodes is however highly challenging due to the parasitic capacitance of the interconnects. Here we employ nanoelectrodes integrated with readout circuitry on the same complementary metal-oxide-semiconductor (CMOS) chip to conduct measurements over a frequency range from 1.6 MHz to 50 MHz. We report the ability to probe the formation of self-assembled monolayers at frequency above 10 MHz in phosphate-buffered saline solution. |
| format | Article |
| id | doaj-art-32fbd89fd31f44068bb5bb42e3db93e3 |
| institution | Kabale University |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensors and Actuators Reports |
| spelling | doaj-art-32fbd89fd31f44068bb5bb42e3db93e32025-02-08T05:01:10ZengElsevierSensors and Actuators Reports2666-05392025-06-019100293High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arraysSelvaraj Chinnathambi0Mohammad Saghafi1Suryasnata Tripathy2Frans P. Widdershoven3Serge G. Lemay4MESA+ Institute and Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The NetherlandsMESA+ Institute and Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The NetherlandsMESA+ Institute and Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The NetherlandsNXP Semiconductors, Technology & Operations/CTO Office, High Tech Campus 46, Eindhoven 5656 AE, The NetherlandsMESA+ Institute and Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands; Corresponding author.Electrochemical impedance spectroscopy is mostly sensitive to the state of the electrode surface at low frequencies, where the electrical properties of the surrounding electrolyte do not yet dominate the response. The available frequency range increases linearly with the inverse electrode size, such that miniaturized electrodes offer the ability to probe the surface at higher frequencies. Measuring the AC response of miniaturized electrodes is however highly challenging due to the parasitic capacitance of the interconnects. Here we employ nanoelectrodes integrated with readout circuitry on the same complementary metal-oxide-semiconductor (CMOS) chip to conduct measurements over a frequency range from 1.6 MHz to 50 MHz. We report the ability to probe the formation of self-assembled monolayers at frequency above 10 MHz in phosphate-buffered saline solution.http://www.sciencedirect.com/science/article/pii/S266605392500013XElectrochemical impedance spectroscopyNanoelectrodeHigh frequencyCMOSSelf-assembled monolayer |
| spellingShingle | Selvaraj Chinnathambi Mohammad Saghafi Suryasnata Tripathy Frans P. Widdershoven Serge G. Lemay High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays Sensors and Actuators Reports Electrochemical impedance spectroscopy Nanoelectrode High frequency CMOS Self-assembled monolayer |
| title | High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays |
| title_full | High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays |
| title_fullStr | High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays |
| title_full_unstemmed | High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays |
| title_short | High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays |
| title_sort | high frequency electrochemical impedance measurements of self assembled monolayer formation using cmos based nanocapacitor arrays |
| topic | Electrochemical impedance spectroscopy Nanoelectrode High frequency CMOS Self-assembled monolayer |
| url | http://www.sciencedirect.com/science/article/pii/S266605392500013X |
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