Neuroplasticity of the Sensorimotor Cortex during Learning
We will discuss some of the current issues in understanding plasticity in the sensorimotor (SM) cortices on the behavioral, neurophysiological, and synaptic levels. We will focus our paper on reaching and grasping movements in the rat. In addition, we will discuss our preliminary work utilizing inhi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/310737 |
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| _version_ | 1849387150916714496 |
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| author | Joseph Thachil Francis Weiguo Song |
| author_facet | Joseph Thachil Francis Weiguo Song |
| author_sort | Joseph Thachil Francis |
| collection | DOAJ |
| description | We will discuss some of the current issues in understanding plasticity in the sensorimotor (SM) cortices on the behavioral, neurophysiological, and synaptic levels. We will focus our paper on reaching and grasping movements in the rat. In addition, we will discuss our preliminary work utilizing inhibition of protein kinase Mζ (PKMζ), which has recently been shown necessary and sufficient for the maintenance of long-term potentiation (LTP) (Ling et al., 2002). With this new knowledge and inhibitors to this system, as well as the ability to overexpress this system, we can start to directly modulate LTP and determine its influence on behavior as well as network level processing dependent at least in part due to this form of LTP. We will also briefly introduce the use of brain machine interface (BMI) paradigms to ask questions about sensorimotor plasticity and discuss current analysis techniques that may help in our understanding of neuroplasticity. |
| format | Article |
| id | doaj-art-32f3374c9b954b199da24b9d5124d470 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-32f3374c9b954b199da24b9d5124d4702025-08-20T03:55:17ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/310737310737Neuroplasticity of the Sensorimotor Cortex during LearningJoseph Thachil Francis0Weiguo Song1Departments of Physiology and Pharmacology, The Robert F. Furchgott Center of Neural and Behavioral Science, and the Joint Program in Biomedical Engineering at SUNY Downstate and NUY-POLY, State University of New York (SUNY) Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartments of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USAWe will discuss some of the current issues in understanding plasticity in the sensorimotor (SM) cortices on the behavioral, neurophysiological, and synaptic levels. We will focus our paper on reaching and grasping movements in the rat. In addition, we will discuss our preliminary work utilizing inhibition of protein kinase Mζ (PKMζ), which has recently been shown necessary and sufficient for the maintenance of long-term potentiation (LTP) (Ling et al., 2002). With this new knowledge and inhibitors to this system, as well as the ability to overexpress this system, we can start to directly modulate LTP and determine its influence on behavior as well as network level processing dependent at least in part due to this form of LTP. We will also briefly introduce the use of brain machine interface (BMI) paradigms to ask questions about sensorimotor plasticity and discuss current analysis techniques that may help in our understanding of neuroplasticity.http://dx.doi.org/10.1155/2011/310737 |
| spellingShingle | Joseph Thachil Francis Weiguo Song Neuroplasticity of the Sensorimotor Cortex during Learning Neural Plasticity |
| title | Neuroplasticity of the Sensorimotor Cortex during Learning |
| title_full | Neuroplasticity of the Sensorimotor Cortex during Learning |
| title_fullStr | Neuroplasticity of the Sensorimotor Cortex during Learning |
| title_full_unstemmed | Neuroplasticity of the Sensorimotor Cortex during Learning |
| title_short | Neuroplasticity of the Sensorimotor Cortex during Learning |
| title_sort | neuroplasticity of the sensorimotor cortex during learning |
| url | http://dx.doi.org/10.1155/2011/310737 |
| work_keys_str_mv | AT josephthachilfrancis neuroplasticityofthesensorimotorcortexduringlearning AT weiguosong neuroplasticityofthesensorimotorcortexduringlearning |