Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient
Various extraglomerular disease processes have been associated with drug-induced secondary minimal change disease (MCD). In a majority of cases, preferably, a hypersensitivity reaction appears to be involved, and in some cases, there is direct toxic effect over glomerular capillaries. There are seve...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/5546942 |
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| author | Satyanand Sathi Anil Kumar Garg Manoj Kumar Singh Virendra Singh Saini Devinder Vohra |
| author_facet | Satyanand Sathi Anil Kumar Garg Manoj Kumar Singh Virendra Singh Saini Devinder Vohra |
| author_sort | Satyanand Sathi |
| collection | DOAJ |
| description | Various extraglomerular disease processes have been associated with drug-induced secondary minimal change disease (MCD). In a majority of cases, preferably, a hypersensitivity reaction appears to be involved, and in some cases, there is direct toxic effect over glomerular capillaries. There are several reports to demonstrate that rifampicin has been associated with various nephrotoxic adverse effects, but rifampicin-induced secondary minimal change disease (MCD) is very rare. Here, we report the case of a young adult male who presented with nephrotic proteinuria with bland urine sediment after one month of initiation of rifampicin treatment for pulmonary tuberculosis. The patient had no proteinuria before the start of antituberculosis treatment. Renal biopsy showed nonproliferative glomerulopathy and immunofluorescence did not show significant glomerular immune deposits. Electron microscopy showed diffuse effacement of visceral epithelial cell foot processes and did not show any presence of glomerular immune complexes and thickening of glomerular basement membrane, promoting the diagnosis of minimal change nephrotic syndrome. The patient got complete remission after discontinuation of rifampicin. |
| format | Article |
| id | doaj-art-32f25fa57e15428dbab2b16ece354f41 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-32f25fa57e15428dbab2b16ece354f412025-08-20T03:55:17ZengWileyCase Reports in Nephrology2090-66412090-665X2021-01-01202110.1155/2021/55469425546942Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis PatientSatyanand Sathi0Anil Kumar Garg1Manoj Kumar Singh2Virendra Singh Saini3Devinder Vohra4Department of Medicine, S.M.M.H. Government Medical College, Saharanpur, Uttar Pradesh, IndiaDepartment of Medicine, S.M.M.H. Government Medical College, Saharanpur, Uttar Pradesh, IndiaDepartment of Medicine, S.M.M.H. Government Medical College, Saharanpur, Uttar Pradesh, IndiaDepartment of Medicine, S.M.M.H. Government Medical College, Saharanpur, Uttar Pradesh, IndiaDepartment of Medicine, S.M.M.H. Government Medical College, Saharanpur, Uttar Pradesh, IndiaVarious extraglomerular disease processes have been associated with drug-induced secondary minimal change disease (MCD). In a majority of cases, preferably, a hypersensitivity reaction appears to be involved, and in some cases, there is direct toxic effect over glomerular capillaries. There are several reports to demonstrate that rifampicin has been associated with various nephrotoxic adverse effects, but rifampicin-induced secondary minimal change disease (MCD) is very rare. Here, we report the case of a young adult male who presented with nephrotic proteinuria with bland urine sediment after one month of initiation of rifampicin treatment for pulmonary tuberculosis. The patient had no proteinuria before the start of antituberculosis treatment. Renal biopsy showed nonproliferative glomerulopathy and immunofluorescence did not show significant glomerular immune deposits. Electron microscopy showed diffuse effacement of visceral epithelial cell foot processes and did not show any presence of glomerular immune complexes and thickening of glomerular basement membrane, promoting the diagnosis of minimal change nephrotic syndrome. The patient got complete remission after discontinuation of rifampicin.http://dx.doi.org/10.1155/2021/5546942 |
| spellingShingle | Satyanand Sathi Anil Kumar Garg Manoj Kumar Singh Virendra Singh Saini Devinder Vohra Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient Case Reports in Nephrology |
| title | Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient |
| title_full | Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient |
| title_fullStr | Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient |
| title_full_unstemmed | Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient |
| title_short | Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient |
| title_sort | rifampicin associated secondary minimal change disease presenting with nephrotic syndrome in a pulmonary tuberculosis patient |
| url | http://dx.doi.org/10.1155/2021/5546942 |
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