Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients
The objective of the study: to investigate the spectrum of drug resistance and genotypes of Mycobacterium tuberculosis isolated from lung surgical specimens of tuberculosis patients.Subjects and methods. Bacteriological testing of surgical specimens of 287 patients operated due to tuberculosis was p...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2019-08-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1309 |
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| author | K. V. Belousovа T. V. Umpelevа N. I. Eremeevа L. A. Golubevа T. Yu. Botevа D. V. Vаkhrushevа |
| author_facet | K. V. Belousovа T. V. Umpelevа N. I. Eremeevа L. A. Golubevа T. Yu. Botevа D. V. Vаkhrushevа |
| author_sort | K. V. Belousovа |
| collection | DOAJ |
| description | The objective of the study: to investigate the spectrum of drug resistance and genotypes of Mycobacterium tuberculosis isolated from lung surgical specimens of tuberculosis patients.Subjects and methods. Bacteriological testing of surgical specimens of 287 patients operated due to tuberculosis was performed. Molecular genetic tests detected Mycobacterium tuberculosis with multiple drug resistance in 66.7% of patients. Test results of 42 samples were compared with culture results and a high level of coincidence was observed for isoniazid (90.9%), rifampicin (89.3%) and fluoroquinolones (81.2%). It was found out that the majority of samples (80.8%) belonged to Beijing family. |
| format | Article |
| id | doaj-art-32f128d5646341efbc43c64d231fa43e |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2019-08-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-32f128d5646341efbc43c64d231fa43e2025-08-20T01:47:52ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062019-08-01977111710.21292/2075-1230-2019-97-7-11-171309Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patientsK. V. Belousovа0T. V. Umpelevа1N. I. Eremeevа2L. A. Golubevа3T. Yu. Botevа4D. V. Vаkhrushevа5Ural Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious DiseasesUral Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious DiseasesUral Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious DiseasesUral Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious DiseasesUral Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious DiseasesUral Phthisiopulmonology Research Institute – a Branch of National Medical Research Center of Phthisiopulmonology and Infectious DiseasesThe objective of the study: to investigate the spectrum of drug resistance and genotypes of Mycobacterium tuberculosis isolated from lung surgical specimens of tuberculosis patients.Subjects and methods. Bacteriological testing of surgical specimens of 287 patients operated due to tuberculosis was performed. Molecular genetic tests detected Mycobacterium tuberculosis with multiple drug resistance in 66.7% of patients. Test results of 42 samples were compared with culture results and a high level of coincidence was observed for isoniazid (90.9%), rifampicin (89.3%) and fluoroquinolones (81.2%). It was found out that the majority of samples (80.8%) belonged to Beijing family.https://www.tibl-journal.com/jour/article/view/1309mycobacterium tuberculosisdrug susceptibilitylung surgical specimensbacteriological diagnosticsbiochip diagnosticstb test |
| spellingShingle | K. V. Belousovа T. V. Umpelevа N. I. Eremeevа L. A. Golubevа T. Yu. Botevа D. V. Vаkhrushevа Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients Туберкулез и болезни лёгких mycobacterium tuberculosis drug susceptibility lung surgical specimens bacteriological diagnostics biochip diagnostics tb test |
| title | Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients |
| title_full | Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients |
| title_fullStr | Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients |
| title_full_unstemmed | Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients |
| title_short | Drug susceptibility and genotype affinity of Mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients |
| title_sort | drug susceptibility and genotype affinity of mycobacterium tuberculosis isolated from surgical specimens of pulmonary tuberculosis patients |
| topic | mycobacterium tuberculosis drug susceptibility lung surgical specimens bacteriological diagnostics biochip diagnostics tb test |
| url | https://www.tibl-journal.com/jour/article/view/1309 |
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