Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China
Abstract Background Varicella-zoster virus (VZV) is highly transmissible; however, there are limited studies in China. Methods The clinical symptoms, disease progression, and laboratory test results of varicella patients among children and adults diagnosed at Ganzhou Fifth People’s Hospital from Aug...
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BMC
2025-02-01
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| Online Access: | https://doi.org/10.1186/s12985-025-02661-6 |
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| author | Ting Zeng Chao-Xian Lian Xiao-Yi Zhang Ping-Qing Liu Jian Ao Gang-Feng Zhou Xiao-Dong Chen Dan-Dan Huang Dian-Gui Hu Xin Chen |
| author_facet | Ting Zeng Chao-Xian Lian Xiao-Yi Zhang Ping-Qing Liu Jian Ao Gang-Feng Zhou Xiao-Dong Chen Dan-Dan Huang Dian-Gui Hu Xin Chen |
| author_sort | Ting Zeng |
| collection | DOAJ |
| description | Abstract Background Varicella-zoster virus (VZV) is highly transmissible; however, there are limited studies in China. Methods The clinical symptoms, disease progression, and laboratory test results of varicella patients among children and adults diagnosed at Ganzhou Fifth People’s Hospital from August 2021 to December 2022 were analysed retrospectively. Genetic polymorphisms in the open reading frame (ORF) 22 and ORF62 fragments of VZV isolates were analysed using molecular epidemiological methods. Results Thirty-nine varicella patients were included in this study, 26 of them were children and 13 of them were adults. The incidence of discomfort and complications was significantly greater in adults than in children (P < 0.05). Four adults developed severe disease, one of whom died, with no cases of severe disease or death among children. The 32 VZV clinical isolates were all Clade 2 wild-type strains. Four variant isolates from children had eight base mutations, five of which were missense; two variant isolates from adults had four base mutations, all of which were missense. Conclusions The risk of developing severe disease or even death after VZV infection in adults was greater than that in children. There is an urgent need for more studies focusing on the differences in the pathogenicity of VZV in different age groups. |
| format | Article |
| id | doaj-art-32f06f2bb15b43daa2b7df4b9f6642b3 |
| institution | DOAJ |
| issn | 1743-422X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj-art-32f06f2bb15b43daa2b7df4b9f6642b32025-08-20T03:10:53ZengBMCVirology Journal1743-422X2025-02-012211810.1186/s12985-025-02661-6Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, ChinaTing Zeng0Chao-Xian Lian1Xiao-Yi Zhang2Ping-Qing Liu3Jian Ao4Gang-Feng Zhou5Xiao-Dong Chen6Dan-Dan Huang7Dian-Gui Hu8Xin Chen9Department of Pathogenic Biology, School of Basic Medical Sciences, Gannan Medical UniversityDepartment of Epidemiology, School of Public Health and Health Management, Gannan Medical UniversityDepartment of Epidemiology, School of Public Health and Health Management, Gannan Medical UniversityDepartment of Infectious Disease, Ganzhou Fifth People’s HospitalDepartment of Infectious Disease, Ganzhou Fifth People’s HospitalDepartment of Infectious Disease, Ganzhou Fifth People’s HospitalDepartment of Infectious Disease, Ganzhou Fifth People’s HospitalDepartment of Pathogenic Biology, School of Basic Medical Sciences, Gannan Medical UniversityDepartment of Infectious Disease, Ganzhou Fifth People’s HospitalDepartment of Pathogenic Biology, School of Basic Medical Sciences, Gannan Medical UniversityAbstract Background Varicella-zoster virus (VZV) is highly transmissible; however, there are limited studies in China. Methods The clinical symptoms, disease progression, and laboratory test results of varicella patients among children and adults diagnosed at Ganzhou Fifth People’s Hospital from August 2021 to December 2022 were analysed retrospectively. Genetic polymorphisms in the open reading frame (ORF) 22 and ORF62 fragments of VZV isolates were analysed using molecular epidemiological methods. Results Thirty-nine varicella patients were included in this study, 26 of them were children and 13 of them were adults. The incidence of discomfort and complications was significantly greater in adults than in children (P < 0.05). Four adults developed severe disease, one of whom died, with no cases of severe disease or death among children. The 32 VZV clinical isolates were all Clade 2 wild-type strains. Four variant isolates from children had eight base mutations, five of which were missense; two variant isolates from adults had four base mutations, all of which were missense. Conclusions The risk of developing severe disease or even death after VZV infection in adults was greater than that in children. There is an urgent need for more studies focusing on the differences in the pathogenicity of VZV in different age groups.https://doi.org/10.1186/s12985-025-02661-6Age groupComplicationGanzhouGenotypeVaricella-Zoster virus |
| spellingShingle | Ting Zeng Chao-Xian Lian Xiao-Yi Zhang Ping-Qing Liu Jian Ao Gang-Feng Zhou Xiao-Dong Chen Dan-Dan Huang Dian-Gui Hu Xin Chen Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China Virology Journal Age group Complication Ganzhou Genotype Varicella-Zoster virus |
| title | Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China |
| title_full | Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China |
| title_fullStr | Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China |
| title_full_unstemmed | Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China |
| title_short | Clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in Ganzhou, China |
| title_sort | clinical symptoms and molecular epidemiologic characteristics of varicella patients among children and adults in ganzhou china |
| topic | Age group Complication Ganzhou Genotype Varicella-Zoster virus |
| url | https://doi.org/10.1186/s12985-025-02661-6 |
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