Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis

Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis

Abstract Background The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton and protein trafficking. Single nucleotide polymorphisms (SNPs) in the CD2AP gene have been associated with Alzheimer’s disease (AD). However, the functional role of...

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Main Authors: Lingliang Zhang, Lingling Huang, Yuhang Zhou, Jian Meng, Liang Zhang, Yunqiang Zhou, Naizhen Zheng, Tiantian Guo, Shanshan Zhao, Zijie Wang, Yuanhui Huo, Yingjun Zhao, Xiao-fen Chen, Honghua Zheng, David M. Holtzman, Yun-wu Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Neurodegeneration
Subjects:
β-amyloid
Alzheimer’s disease
C1q
CD2AP
CSF1R
Disease-associated microglia
Online Access:https://doi.org/10.1186/s13024-024-00789-7
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