Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease

Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease

BackgroundIron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer’s disease (AD) and can be measured using quantitative susceptibility mapping (QSM). However, it is unclear if iron measured using QSM is regionally related to tau in atypical presen...

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Bibliographic Details
Main Authors: Neha Singh-Reilly, Ryota Satoh, Jonathan Graff-Radford, Mary M. Machulda, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
atypical Alzheimer’s disease
QSM
iron burden
tau-PET
tau accumulation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1615718/full
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