Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease
BackgroundIron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer’s disease (AD) and can be measured using quantitative susceptibility mapping (QSM). However, it is unclear if iron measured using QSM is regionally related to tau in atypical presen...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1615718/full |
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| author | Neha Singh-Reilly Ryota Satoh Jonathan Graff-Radford Mary M. Machulda Val J. Lowe Keith A. Josephs Jennifer L. Whitwell |
| author_facet | Neha Singh-Reilly Ryota Satoh Jonathan Graff-Radford Mary M. Machulda Val J. Lowe Keith A. Josephs Jennifer L. Whitwell |
| author_sort | Neha Singh-Reilly |
| collection | DOAJ |
| description | BackgroundIron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer’s disease (AD) and can be measured using quantitative susceptibility mapping (QSM). However, it is unclear if iron measured using QSM is regionally related to tau in atypical presentations of AD.MethodsForty patients with atypical AD underwent a 3 T magnetic resonance imaging (MRI) scan with a five-echo gradient echo sequence to calculate QSM, Aβ, and [18F] AV-1451 positron emission tomography (PET). The relationship between QSM and tau-PET was assessed using voxel-based regression analysis using whole brain VoxelStats and region-of-interest (ROI)-based Spearman’s correlation analyses using cortical and subcortical ROIs.ResultsAt the voxel-level, positive correlations between tau-PET and QSM were only observed in the left caudate. At the ROI-level, a positive association was observed between tau-PET and susceptibility in the occipital lobe and a negative association was observed between substantia nigra susceptibility and occipital tau-PET uptake, although these findings did not survive correction for multiple comparisons.DiscussionOur data provides little evidence that regional tau-PET uptake is related to susceptibility changes, suggesting that iron deposition may not be directly associated with tau accumulation in atypical AD. |
| format | Article |
| id | doaj-art-32ddb9cc202f4ccd8b8d20c32d219d6b |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-32ddb9cc202f4ccd8b8d20c32d219d6b2025-08-20T03:31:10ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-07-011710.3389/fnagi.2025.16157181615718Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s diseaseNeha Singh-Reilly0Ryota Satoh1Jonathan Graff-Radford2Mary M. Machulda3Val J. Lowe4Keith A. Josephs5Jennifer L. Whitwell6Department of Radiology, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiology, Mayo Clinic, Rochester, MN, United StatesDepartment of Neurology, Mayo Clinic, Rochester, MN, United StatesDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiology, Mayo Clinic, Rochester, MN, United StatesDepartment of Neurology, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiology, Mayo Clinic, Rochester, MN, United StatesBackgroundIron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer’s disease (AD) and can be measured using quantitative susceptibility mapping (QSM). However, it is unclear if iron measured using QSM is regionally related to tau in atypical presentations of AD.MethodsForty patients with atypical AD underwent a 3 T magnetic resonance imaging (MRI) scan with a five-echo gradient echo sequence to calculate QSM, Aβ, and [18F] AV-1451 positron emission tomography (PET). The relationship between QSM and tau-PET was assessed using voxel-based regression analysis using whole brain VoxelStats and region-of-interest (ROI)-based Spearman’s correlation analyses using cortical and subcortical ROIs.ResultsAt the voxel-level, positive correlations between tau-PET and QSM were only observed in the left caudate. At the ROI-level, a positive association was observed between tau-PET and susceptibility in the occipital lobe and a negative association was observed between substantia nigra susceptibility and occipital tau-PET uptake, although these findings did not survive correction for multiple comparisons.DiscussionOur data provides little evidence that regional tau-PET uptake is related to susceptibility changes, suggesting that iron deposition may not be directly associated with tau accumulation in atypical AD.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1615718/fullatypical Alzheimer’s diseaseQSMiron burdentau-PETtau accumulation |
| spellingShingle | Neha Singh-Reilly Ryota Satoh Jonathan Graff-Radford Mary M. Machulda Val J. Lowe Keith A. Josephs Jennifer L. Whitwell Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease Frontiers in Aging Neuroscience atypical Alzheimer’s disease QSM iron burden tau-PET tau accumulation |
| title | Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease |
| title_full | Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease |
| title_fullStr | Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease |
| title_full_unstemmed | Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease |
| title_short | Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease |
| title_sort | relationship between tau pet and quantitative susceptibility mapping in atypical alzheimer s disease |
| topic | atypical Alzheimer’s disease QSM iron burden tau-PET tau accumulation |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1615718/full |
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