Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, posing obstetrical and metabolic risks. While emerging evidence suggests an association between specific metal exposure and GDM, the crucial metabolic changes between serum metal exposure and GDM risk have yet to be fully cla...
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Elsevier
2025-08-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325008632 |
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| author | Xu Yang Jingjing Han Flores Carpintero Rigoberto Yadan Xu Yifan Xu Mingzhi Zhang Hein Min Tun Bo Hang Yankai Xia |
| author_facet | Xu Yang Jingjing Han Flores Carpintero Rigoberto Yadan Xu Yifan Xu Mingzhi Zhang Hein Min Tun Bo Hang Yankai Xia |
| author_sort | Xu Yang |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is a common complication of pregnancy, posing obstetrical and metabolic risks. While emerging evidence suggests an association between specific metal exposure and GDM, the crucial metabolic changes between serum metal exposure and GDM risk have yet to be fully clarified. Here we employed a combination of bibliometric and epidemiological methodologies to investigate the relationship between metal exposure and GDM and potential mediation role of metabolites in Chinese pregnant women. Our findings revealed an increasing research interest in the association of serum metal levels with GDM. Epidemiologically, metals such as iron (Fe) and molybdenum (Mo) were found to be negatively associated with GDM based on single-metal models with ORs being 0.325 (95 % CI: 0.138, 0.768) and 0.030 (95 % CI: 0.002, 0.439), respectively. A joint negative effect from metal co-exposure on GDM was shown, with Fe and Mo identified as the key metals. 7β-hydroxycholesterol mediated 9.9 % of the association between Fe and GDM risk, while melatonin mediated 7.8 % of the association between Mo and GDM risk. Our study provides new perspectives for understanding the beneficial effect of essential metals on GDM and lays a solid foundation for further validation through multicenter investigations and for exploration of mechanisms through in vivo studies. |
| format | Article |
| id | doaj-art-32d680d0bdaa49ea8b462551d642b23a |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-32d680d0bdaa49ea8b462551d642b23a2025-08-20T03:30:44ZengElsevierEcotoxicology and Environmental Safety0147-65132025-08-0130111851810.1016/j.ecoenv.2025.118518Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analysesXu Yang0Jingjing Han1Flores Carpintero Rigoberto2Yadan Xu3Yifan Xu4Mingzhi Zhang5Hein Min Tun6Bo Hang7Yankai Xia8State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China; Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of clinical laboratory medicine, Children's Hospital of Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, ChinaThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong; Microbiota I-Center (MagIC), Hong KongBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USAState Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China; Corresponding authors at: State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, No.101 Longmian Road, Nanjing 211166, China.Gestational diabetes mellitus (GDM) is a common complication of pregnancy, posing obstetrical and metabolic risks. While emerging evidence suggests an association between specific metal exposure and GDM, the crucial metabolic changes between serum metal exposure and GDM risk have yet to be fully clarified. Here we employed a combination of bibliometric and epidemiological methodologies to investigate the relationship between metal exposure and GDM and potential mediation role of metabolites in Chinese pregnant women. Our findings revealed an increasing research interest in the association of serum metal levels with GDM. Epidemiologically, metals such as iron (Fe) and molybdenum (Mo) were found to be negatively associated with GDM based on single-metal models with ORs being 0.325 (95 % CI: 0.138, 0.768) and 0.030 (95 % CI: 0.002, 0.439), respectively. A joint negative effect from metal co-exposure on GDM was shown, with Fe and Mo identified as the key metals. 7β-hydroxycholesterol mediated 9.9 % of the association between Fe and GDM risk, while melatonin mediated 7.8 % of the association between Mo and GDM risk. Our study provides new perspectives for understanding the beneficial effect of essential metals on GDM and lays a solid foundation for further validation through multicenter investigations and for exploration of mechanisms through in vivo studies.http://www.sciencedirect.com/science/article/pii/S0147651325008632Metal exposureGestational diabetes mellitusJoint effectMetabolomics |
| spellingShingle | Xu Yang Jingjing Han Flores Carpintero Rigoberto Yadan Xu Yifan Xu Mingzhi Zhang Hein Min Tun Bo Hang Yankai Xia Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses Ecotoxicology and Environmental Safety Metal exposure Gestational diabetes mellitus Joint effect Metabolomics |
| title | Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses |
| title_full | Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses |
| title_fullStr | Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses |
| title_full_unstemmed | Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses |
| title_short | Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses |
| title_sort | risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in chinese population a dual approach using bibliometric and epidemiological analyses |
| topic | Metal exposure Gestational diabetes mellitus Joint effect Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325008632 |
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