Exploring the impact of neutrophils on lung adenocarcinoma using Mendelian randomization and transcriptomic study

Exploring the impact of neutrophils on lung adenocarcinoma using Mendelian randomization and transcriptomic study

Abstract Tumor immune microenvironment plays a crucial role in determining the prognosis of lung adenocarcinoma (LUAD), with the interaction of immune cells within this microenvironment contributing to a poorer prognosis. We sought to investigate the causal relationship and underlying biological mec...

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Bibliographic Details
Main Authors: Xiang Xiao, Xuan-Yu Wu, Jing-Qi Zhang, Wen-Yuan Li, Feng-Ming You, Jing Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Lung adenocarcinoma
Immune cell characteristics
Neutrophil
Mendelian randomization
Single-cell RNA-sequencing
Bulk RNA-sequencing
Online Access:https://doi.org/10.1038/s41598-025-08490-5
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