Carcinogenesis in Chronic Ulcerative Colitis: Flow Cytometry
Flow cytometry is a conceptually straightforward quantitative method that can be used to determine the DNA content (and many other parameters) of individual cells. It has been used in chronic ulcerative colitis to evaluate the presence of aneuploidy as a marker of colon cancer risk. In this paper, t...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/981048 |
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| Summary: | Flow cytometry is a conceptually straightforward quantitative
method that can be used to determine the DNA content (and many other
parameters) of individual cells. It has been used in chronic ulcerative colitis to
evaluate the presence of aneuploidy as a marker of colon cancer risk. In this paper,
the basic principles of flow cytometry are reviewed, the current status of published
studies using flow cytometric analysis of DNA content in chronic ulcerative
colitis outlined, conclusions from the research are proposed and future research
needs identified. Overall, aneuploidy correlates with the current best markers of
cancer risk in ulcerative colitis, ie, dysplasia and established cancer. Whether
aneuplo1dy will be useful for the prospective identification of individuals at
increased risk for colon cancer deserves rigorous evaluation. An important
technical issue of potential variability in interpretation of near diploid peaks is
emphasized. |
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| ISSN: | 0835-7900 |