The Complex Role of STAT3 in Viral Infections
Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/272359 |
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| _version_ | 1832568060133769216 |
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| author | Suresh V. Kuchipudi |
| author_facet | Suresh V. Kuchipudi |
| author_sort | Suresh V. Kuchipudi |
| collection | DOAJ |
| description | Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. This review summarized the currently known functions of STAT3 in the regulation of viral replication and pathogenesis of viral infections. Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed. |
| format | Article |
| id | doaj-art-32cd5e11c16349489787aacf6393bb81 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-32cd5e11c16349489787aacf6393bb812025-02-03T00:59:49ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/272359272359The Complex Role of STAT3 in Viral InfectionsSuresh V. Kuchipudi0School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UKSignal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. In addition, STAT3 plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. This review summarized the currently known functions of STAT3 in the regulation of viral replication and pathogenesis of viral infections. Some of the key unanswered questions and the gap in our current understanding of the role of STAT3 in viral pathogenesis are discussed.http://dx.doi.org/10.1155/2015/272359 |
| spellingShingle | Suresh V. Kuchipudi The Complex Role of STAT3 in Viral Infections Journal of Immunology Research |
| title | The Complex Role of STAT3 in Viral Infections |
| title_full | The Complex Role of STAT3 in Viral Infections |
| title_fullStr | The Complex Role of STAT3 in Viral Infections |
| title_full_unstemmed | The Complex Role of STAT3 in Viral Infections |
| title_short | The Complex Role of STAT3 in Viral Infections |
| title_sort | complex role of stat3 in viral infections |
| url | http://dx.doi.org/10.1155/2015/272359 |
| work_keys_str_mv | AT sureshvkuchipudi thecomplexroleofstat3inviralinfections AT sureshvkuchipudi complexroleofstat3inviralinfections |