Untargeted Metabolomic Study of Patients with Macular Edema Secondary to Retinal Vein Occlusion in Aqueous Humor
Qingquan Wei, Liying Luo, Yingjun Min, Yingying Gong, Li Wang Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Li Wang, Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University S...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-01-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/untargeted-metabolomic-study-of-patients-with-macular-edema-secondary--peer-reviewed-fulltext-article-OPTH |
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| Summary: | Qingquan Wei, Liying Luo, Yingjun Min, Yingying Gong, Li Wang Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Li Wang, Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, Email WL1249@shtrhospital.comPurpose: The aim of this study was to identify metabolic biomarkers and investigate the metabolic changes associated with aqueous humor in retinal vein occlusion macular edema (RVO-ME).Methods: Aqueous humor (AH) samples were collected from patients, including those diagnosed with central retinal vein occlusion macular edema (CRVO-ME), branch retinal vein occlusion macular edema (BRVO-ME), and a control group undergoing cataract surgery. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized to analyze the metabolomic profiles in aqueous humor.Results: A total of 28 metabolites were identified as potential biomarkers capable of distinguishing RVO-ME patients from the control group. Of these, 26 metabolites were specific for distinguishing CRVO-ME patients from controls, and 24 metabolites were specific for differentiating BRVO-ME patients from controls. Additionally, 9 metabolites were identified that could differentiate CRVO-ME patients from BRVO-ME patients.Conclusion: This study successfully identified significant metabolic biomarkers that enhance our understanding of the pathogenesis of RVO-ME. These findings may offer new avenues for the treatment of RVO-ME and aid in differentiating between CRVO-ME and BRVO-ME patients.Keywords: metabolomic, retinal vein occlusion, macular edema, aqueous humor |
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| ISSN: | 1177-5483 |